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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
DP 1
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "DP 1" in MCE Product Catalog:
2
Target:
Research Areas:
Cardiovascular Disease Inflammation/Immunology Endocrinology
Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
2
Target:
Research Areas:
Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
2
Target:
Research Areas:
Treprostinil (UT-15C) diethanolamine is a potent EP2, DP1 and IP agonist with Ki values of 3.6, 4.4, 32.1, 212, 826, 2505 and 4680 nM for EP2, DP1, IP, EP1, EP4, EP3 and FP, respectively. Treprostinil (UT-15C) diethanolamine increases upregulation of cAMP toward maintaining homeostasis within the vasculature. Treprostinil (UT-15C) diethanolamine can result in vasodilatation of human pulmonary arteries .
1
Target:
Research Areas:
Asapiprant is a potent and selective DP1 receptor antagonist with a Ki of 0.44 nM.
1
1 Cited Publications
Cat. No.: HY-18971
CAS No.: 1164462-05-8
Target:
Research Areas:
Neurological Disease Inflammation/Immunology Endocrinology Cancer
TG4-155 is a potent, brain-permeant and selective EP2 receptor antagonist with a Ki of 9.9 nM . TG4-155 shows low nanomolar antagonist activity against only EP2 and DP1 . TG4-155 has an EP2 Schild KB of 2.4 nM and displays 550-4750-fold selectivity for EP2 over EP1, EP3, EP4 and IP, but only 14-fold selectivity against the DP1 receptor .
Target:
Research Areas:
BW 245C is a prostanoid DP-receptor (DP1) agonist, used to study stroke.
Synonyms: AMG 853
Target:
Research Areas:
Vidupiprant (AMG 853) is a phenylacetic acid derivative. Vidupiprant is a potent and orally active CRTH2 (DP2) and prostanoid D receptor (DP or DP1) dual antagonist with IC50s of 3 nM and 4 nM in buffer, and 8 nM and 35 nM in human plasma, respectively. Vidupiprant has the potential for asthma treatment .
Cat. No.: HY-16751
CAS No.: 1187856-49-0
Synonyms: APD811
Target:
Research Areas:
Ralinepag is a potent, orally bioavailable and non-prostanoid prostacyclin (IP) receptor agonist, with EC50s of 8.5 nM, 530 nM and 850 nM for human and rat IP receptor and human DP1 receptor, respectively.
Target:
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DP-1, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity .
Synonyms: UT-15-d9
Target:
Research Areas:
L 888607 Racemate is a selective prostaglandin D2 receptor subtype 1 (DP1) antagonist, with Kis of 132 nM and 17 nM for DP1 and thromboxane A2 receptor (TP), respectively.
Cat. No.: HY-132995A
CAS No.: 1472616-35-5
Target:
Research Areas:
DP-1 hydrochloride, a degradation product of SDC-TRAP-0063, is a fragment of Ganetespib. Ganetespib is a heat shock protein 90 (HSP90) inhibitor with anti-tumor activity .
Synonyms: 15(R)-15-Methyl PGD2
Target:
Research Areas:
15(R)-15-Methyl prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2. The physiological actions of PGD2 include regulation of sleep, lowering of body temperature, inhibition of platelet aggregation and relaxation of vascular smooth muscle. PGD2 mediates its effects by 2 distinct G-protein-coupled receptors, DP1and CRTH2/DP2. 15(R)-15-Methyl prostaglandin D2 is a potent, selective agonist for the CRTH2/DP2 receptor. The EC50 values for eosinophil CD11b expression, actin polymerization, and chemotaxis are 1.4, 3.8, and 1.7 nM, respectively, each of which is approximately 3-5 fold lower than those for PGD2. In contrast the EC50 for the DP1-mediated increase in platelet cAMP by 15(R)-15-methyl PGD2 is >10 μM.
Cat. No.: HY-P11167
CAS No.: 1346415-30-2
Cat. No.: HY-P11858
Research Areas:
Cat. No.: HY-100441S1
Synonyms: UT-15-13C2,d1
Cat. No.: HY-100441S3
Synonyms: UT-15-d7
Cat. No.: HY-172561
Target:
Research Areas:
15-Keto treprostinil sodium is an impurity in Treprostinil (HY-100441). Treprostinil is a potent DP1 and EP2 agonist .
Cat. No.: HY-100441R
CAS No.: 81846-19-7
Synonyms: UT-15 (Standard)
Research Areas:
Treprostinil (Standard) is the analytical standard of Treprostinil. This product is intended for research and analytical applications. Treprostinil (UT-15) is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
Cat. No.: HY-16504R
CAS No.: 289480-64-4
Synonyms: UT-15 sodium (Standard)
Research Areas:
Treprostinil (sodium) (Standard) is the analytical standard of Treprostinil (sodium). This product is intended for research and analytical applications. Treprostinil (UT-15) sodium is a potent DP1 and EP2 agonist with EC50 values of 0.6±0.1 and 6.2±1.2 nM, respectively.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
