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Endothelin-3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Endothelin Receptor (6) Drug Intermediate (1) Integrin (2)
By Research Areas:	Cancer (1) Cardiovascular Disease (3) Neurological Disease (5)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Targets Recommended: Endothelin Receptor Endothelin-Converting Enzyme (ECE)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) TFA	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat 1 Publications Verification Endothelin 3 (Rat,Human)	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P3571

*[Ala2] Endothelin-3, human*	Endothelin Receptor	Cancer
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells .

HY-P11605

*Big endothelin-3* (Human, 1-41 amide)**	Drug Intermediate Endothelin Receptor	Cardiovascular Disease Neurological Disease
Big endothelin-3 (Human, 1-41 amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide composing of 41 amino acids .

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

Cat. No.	Product Name	Target	Research Area

HY-P0204A

Endothelin-3, human, mouse, rabbit, rat TFA 1 Publications Verification Endothelin 3 (Rat,Human) TFA	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat TFA (Endothelin 3 (Rat,Human) TFA) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat TFA stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat TFA plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat TFA acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat TFA can be used in studies related to distal aganglionosis .

HY-P0204

Endothelin-3, human, mouse, rabbit, rat 1 Publications Verification Endothelin 3 (Rat,Human)	Endothelin Receptor Integrin	Neurological Disease
Endothelin-3, human, mouse, rabbit, rat (Endothelin 3 (Rat,Human)) is an adhesion stimulant. Endothelin-3, human, mouse, rabbit, rat stimulates the adhesion of enteric neural crest cells to various ECM components. Endothelin-3, human, mouse, rabbit, rat plays an important role in the maintenance and self-renewal of intestinal progenitor cells, participates in the migration of enteric neural crest cells, and helps maintain a suitable environment for the colonization of enteric neural crest cells. Endothelin-3, human, mouse, rabbit, rat acts synergistically with the β1-integrin signaling pathway during enteric nervous system development. Endothelin-3, human, mouse, rabbit, rat can be used in studies related to distal aganglionosis .

HY-P1112

Sarafotoxin S6a	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a, a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

HY-P4915

*Big Endothelin-3* (22-41) amide (human)**	Peptides	Others
Big Endothelin-3 (22-41) amide (human) is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .

HY-P3571

*[Ala2] Endothelin-3, human*	Endothelin Receptor	Cancer
[Ala2] Endothelin-3, human is a linear analog of endothelin-3 (ET-3) where substitution of Ala for Cys residues. TE-3 is a vasoactive peptide, produced by human rhabdomyosarcoma cell lines, whereas it is not expressed by human sarcoma cell lines of non-muscle origin. ET-3 acts as a paracrine factor, since it promotes migration of endothelial cells .

HY-P11605

*Big endothelin-3* (Human, 1-41 amide)**	Drug Intermediate Endothelin Receptor	Cardiovascular Disease Neurological Disease
Big endothelin-3 (Human, 1-41 amide) is a precursor molecule of the Endothelin-3 (ET-3) peptide composing of 41 amino acids .

HY-P1112A

Sarafotoxin S6a TFA	Endothelin Receptor	Cardiovascular Disease Neurological Disease
Sarafotoxin S6a TFA , a sarafotoxin analogue, is a endothelin receptor agonist and has an ET_A/ET_B selectivity profile similar to that of Endothelin-3 (HY-P0204). Sarafotoxin S6a TFA elicits the pig coronary artery with an EC₅₀ value of 7.5 nM .

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P704078

	Endothelin-3/EDN3 Protein, Human (P. pastoris, His, Myc) ET-3; PreproEndothelin-3; PPET3	Human	P. pastoris
	Endothelin-3/EDN3 Protein, Human (P. pastoris, His, Myc) is the recombinant human-derived Endothelin-3/EDN3 protein, expressed by P. pastoris, with C-6*His & C-Myc tag.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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