23 Results for "

G1-kappa

" in MedChemExpress (MCE) Product Catalog:
Products (23)

23 Results for "G1-kappa" in MCE Product Catalog:

Cat. No.: HY-P99367
CAS No.: 2484870-90-6
Synonyms: DS-7300a Antibody; MABX-9001A Antibody

Target:  

CD276/B7-H3

Research Areas:  

Inflammation/Immunology Cancer

Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur [1].
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Cat. No.: HY-P990047
CAS No.: 2761478-99-1
Synonyms: AMG133 antibody

Research Areas:  

Metabolic Disease

Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes [1] .
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Cat. No.: HY-P990028
CAS No.: 2610074-56-9

Research Areas:  

Cancer

Raludotatug is a humanized anti-CDH6 IgG1 monoclonal antibody. Raludotatug has antitumor activity and can be used to synthesize the ADC molecule Raludotatug deruxtecan (HY-164734) [1].
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Cat. No.: HY-P99521
CAS No.: 2138442-13-2
Synonyms: XmAb14045

Target:  

CD3

Research Areas:  

Inflammation/Immunology Cancer

Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 [1] .
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Cat. No.: HY-P990045
CAS No.: 2749515-10-2
Synonyms: ALE.F02

Target:  

Claudin

Research Areas:  

Endocrinology

Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis [1].
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Cat. No.: HY-P99382
CAS No.: 2039148-04-2
Synonyms: JTX 2011; 37A10

Target:  

Inhibitory Antibodies

Research Areas:  

Inflammation/Immunology Cancer

Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response [1].
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Cat. No.: HY-P990032
CAS No.: 2574438-65-4
Synonyms: EOS-448; EOS884448; GSK4428859A
Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer [1] .
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Cat. No.: HY-P990048
CAS No.: 2750031-18-4
Synonyms: ADG126

Target:  

CTLA-4

Research Areas:  

Cancer

Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic [1].
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Cat. No.: HY-P990947
CAS No.: 2868265-50-1
Synonyms: AZD9592 Antibody

Target:  

ADC Antibodies EGFR

Research Areas:  

Cancer

Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the Top1 inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) [1].
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Cat. No.: HY-P99698
CAS No.: 2475402-56-1
Synonyms: LDP

Target:  

PD-1/PD-L1

Research Areas:  

Inflammation/Immunology Cancer

Lesabelimab (LDP) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor [1] .
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Cat. No.: HY-P990079
CAS No.: 2725062-35-9
Synonyms: BMS-986207; ONO-4686

Target:  

CD28

Research Areas:  

Inflammation/Immunology

Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody [1].
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Cat. No.: HY-P99963
CAS No.: 2387417-06-1
Synonyms: HS636

Target:  

PD-1/PD-L1

Research Areas:  

Cancer

Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment [1].
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Cat. No.: HY-P990020
CAS No.: 2518200-21-8
Synonyms: FSI-174

Target:  

c-Kit

Research Areas:  

Others

Eglatoprutug is an humanized immunoglobulin G1-kappa, anti-c-Kit monoclonal antibody [1].
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Cat. No.: HY-147407
Target:  

EGFR

Research Areas:  

Cancer

Imbotolimod, immunoglobulin G1-kappa, is a humanized monoclonal antibody with anti-ERBB2 and antineoplastic activity. Imbotolimod is a derivative of telratolimod [1].
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Cat. No.: HY-P990080
CAS No.: 2649371-19-5
Synonyms: BMS-986249

Target:  

CTLA-4

Research Areas:  

Cancer

Sovipostobart is an immunoglobulin G1-kappa, anti-CTLA-4 human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic [1].
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Cat. No.: HY-P991135
CAS No.: 2999644-88-9
Synonyms: RO-7502175; RG-6411

Target:  

CCR

Research Areas:  

Cancer

Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies [1].
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Cat. No.: HY-P991153
CAS No.: 2923558-06-7

Target:  

Virus Protease

Research Areas:  

Infection

Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation [1].
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Cat. No.: HY-P991134
CAS No.: 2832924-76-0
Synonyms: VRDN-003; ZL-1109

Target:  

IGF-1R

Research Areas:  

Inflammation/Immunology

Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease [1].
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Cat. No.: HY-P991461
Synonyms: XmAb968

Target:  

CD38

Research Areas:  

Cancer

AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 [1].
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Cat. No.: HY-P991139
CAS No.: 3014361-57-7
Synonyms: YH-001; C-17226

Target:  

CTLA-4

Research Areas:  

Cancer

Futermestotug is a humanized immunoglobulin G1-κ monoclonal antibody targeting human cytotoxic T-lymphocyte associated protein 4 (CTLA4). Futermestotug is promising for research of various malignant tumors [1].
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