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Results for "

G1-kappa

" in MedChemExpress (MCE) Product Catalog:

23

Inhibitors & Agonists

24

Inhibitory Antibodies

Cat. No. Product Name Target Research Area Image
  • HY-P99367
    Ifinatamab

    DS-7300a Antibody; MABX-9001A Antibody

    		 CD276/B7-H3 Inflammation/Immunology Cancer
    Ifinatamab is monoclonal immunoglobulin G1-kappa with anti-human B7 homolog 3 protein (Human B7-H3). Ifinatamab is a glycoforme α immunomodulateur [1].
    Ifinatamab
  • HY-P990047
    Maridebart

    AMG133 antibody

    		 ADC Antibody GLP Receptor Metabolic Disease
    Maridebart (AMG133 antibody) is a human immunoglobulin G1-kappa, anti-GIPR (gastric inhibitory polypeptide receptor) monoclonal antibody. Maridebart is the antibody portion of Maridebart cafraglutide (HY-164535) and can be used for the synthesis of antibody-drug conjugates (ADC). Maridebart can be used for the reserrch of obesity and type 2 diabetes [1] .
    Maridebart
  • HY-P990028
    Raludotatug

    		ADC Antibody Transmembrane Glycoprotein Cancer
    Raludotatug is a humanized anti-CDH6 IgG1 monoclonal antibody. Raludotatug has antitumor activity and can be used to synthesize the ADC molecule Raludotatug deruxtecan (HY-164734) [1].
    Raludotatug
  • HY-P99521
    Vibecotamab

    XmAb14045

    		 CD3 Inflammation/Immunology Cancer
    Vibecotamab (XmAb14045) is a potent bispecific antibody targeting both CD123 and CD3. Vibecotamab targets T cell-mediated killing of CD123-expressing cells, regardless of T cell antigen specificity. Vibecotamab is a full length immunoglobulin molecule. Vibecotamab can be studied in research for diseases such as Myelodysplastic syndrome and acute myeloid leukemia. Recommend Isotype Control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 [1] .
    Vibecotamab
  • HY-P990045
    Lixudebart

    ALE.F02

    		 Claudin Endocrinology
    Lixudebart (ALE.F02) is a humanized immunoglobulin G1-kappa, anti-CLDN1 monoclonal antibody. Lixudebart disrupts CLDN1 interactions with CD44 and MMP14, reduces renal macrophage infiltration, epithelial activation, and urinary albumin-to-creatinine ratio, and attenuates glomerulosclerosis. Lixudebart can be used for the research of focal segmental glomerulosclerosis [1].
    Lixudebart
  • HY-P99382
    Vopratelimab

    JTX 2011; 37A10

    		 Inhibitory Antibodies Inflammation/Immunology Cancer
    Vopratelimab (JTX-2011) is a humanized immunoglobulin G1-kappa agonist monoclonal antibody that pecifically binds to the Inducible CO-Stimulator of T cells (ICOS). Vopratelimab retains species cross-reactivity with affinities of 0.93 nM to hICOS, 0.46 nM to cynomolgus ICOS, 3.7 nM to rat ICOS, and 0.64 nM to mICOS. Vopratelimab has antitumor immune response [1].
    Vopratelimab
  • HY-P990032
    Belrestotug

    EOS-448; EOS884448; GSK4428859A

    		 Transmembrane Glycoprotein Inflammation/Immunology Cancer
    Belrestotug (EOS-448) is an antagonistic anti-TIGIT (VSIG9, VSTM3) human immunoglobulin G1 kappa (hIgG1 kappa) antibody. Belrestotug shows antineoplastic activity. Belrestotug can be used for cancer and immunological research such as colon cancer [1] .
    Belrestotug
  • HY-P990048
    Muzastotug

    ADG126

    		 CTLA-4 Cancer
    Muzastotug is a humanized immunoglobulin G1-kappa, anti-CTLA4 monoclonal antibody. Muzastotug is an immunostimulant and antineoplastic [1].
    Muzastotug
  • HY-P990947
    Tilatamig

    AZD9592 Antibody

    		 ADC Antibody EGFR Cancer
    Tilatamig (AZD9592 Antibody) is a human antibody of the Ig (G1-κ_G1-λ2) subtype that targets EGFR/MET. Tilatamig conjugates with the Top1 inhibitor AZ14170133 (HY-145399) to form the antibody-drug conjugate (ADC) Tilatamig samrotecan (HY-171124) (AZD9592). Tilatamig accurately targets NSCLC models including EGFR-mutant, EGFR-wildtype, and EGFR tyrosine kinase inhibitor-treated ones, and its activity correlates with high expression of EGFR, c-MET and SLFN11. Tilatamig is available for in vivo anti-tumor studies in patient-derived xenograft models of non-small cell lung cancer (NSCLC) and head and neck squamous cell carcinoma (HNSCC) [1].
    Tilatamig
  • HY-P99698
    Lesabelimab

    LDP

    		 PD-1/PD-L1 Inflammation/Immunology Cancer
    Lesabelimab (LDP) is an immunoglobulin G1-kappa anti-CD274 monoclonal antibody. CD274 is an immune checkpoint ligand, represses antitumour immunity through the interaction with PDCD1 receptor [1] .
    Lesabelimab
  • HY-P990079
    Renvistobart

    BMS-986207; ONO-4686

    		 CD28 Inflammation/Immunology
    Renvistobart is an immunoglobulin G1-κ, anti-[Homo sapiens TIGIT (T cell immunoreceptor with Ig domain and ITIM, VSIG9, VSTM3)] Homo sapiens monoclonal antibody [1].
    Renvistobart
  • HY-P99963
    Sudubrilimab

    HS636

    		 PD-1/PD-L1 Cancer
    Sudubrilimab (HS636) is an Ig G1-kappa monoclonal antibody against PDL1. Sudubrilimab is fused at the C terminus of the heavy chain to a TGF-β1 receptor Ⅱ ectodomain (TGFBR2-ECD), and which can sequester the PD-1/PD-L1 pathway and TGF-β bioactivity in the immunosuppressive tumor microenvironment [1].
    Sudubrilimab
  • HY-P990020
    Eglatoprutug

    FSI-174

    		 c-Kit Others
    Eglatoprutug is an humanized immunoglobulin G1-kappa, anti-c-Kit monoclonal antibody [1].
    Eglatoprutug
  • HY-P990039
    Falbikitug

    		Inhibitory Antibodies Cancer
    Falbikitug is a humanized immunoglobulin G1-kappa, anti-LIF monoclonal antibody. Falbikitug is an antineoplastic [1].
    Falbikitug
  • HY-P990080
    Sovipostobart

    BMS-986249

    		 CTLA-4 Cancer
    Sovipostobart is an immunoglobulin G1-kappa, anti-CTLA-4 human monoclonal antibody with cleavable prodomain. Sovipostobart is an immunostimulant and antineoplastic [1].
    Sovipostobart
  • HY-P991135
    Enzelkitug

    RO-7502175; RG-6411

    		 CCR Cancer
    Enzelkitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the human C-C motif chemokine receptor 8 (CCR8). Enzelkitug is promising for research of various solid tumors and hematological malignancies [1].
    Enzelkitug
  • HY-P991153
    Potravitug

    		Virus Protease Infection
    Potravitug is a humanized immunoglobulin G1-κ monoclonal antibody targeting the major capsid protein VP1 of BK polyomavirus (BKV). Potravitug is promising for research of BKV-infection-related diseases, such as BKV-induced nephropathy after organ transplantation [1].
    Potravitug
  • HY-P991134
    Elegrobart

    		IGF-1R Inflammation/Immunology
    Elegrobart is an immunoglobulin G1-κ monoclonal antibody targeting the human insulin-like growth factor 1 receptor (IGF1R). Elegrobart is promising for research of diseases associated with abnormal IGF1R signaling, especially thyroid eye disease [1].
    Elegrobart
  • HY-P991461
    AMG-424

    XmAb968

    		 CD38 Cancer
    AMG-424 (XmAb968) is a human bispecific antibody (bsAb) targeting CD38 & CD3E. AMG-424 kills CD38-expressing cancer cells, triggers T-cell proliferation and attenuates cytokine release. AMG 424 has antitumor activity in a bone marrow-invasive mouse cancer model and induces peripheral B-cell depletion in cynomolgus monkeys. AMG-424 can be used in multiple myeloma research. Recommended isotype control: half-IG G1-kappa/(scFv-heavy-lambda)-h-CH2-CH3 [1].
    AMG-424
  • HY-P991139
    Futermestotug

    		CTLA-4 Cancer
    Futermestotug is a humanized immunoglobulin G1-κ monoclonal antibody targeting human cytotoxic T-lymphocyte associated protein 4 (CTLA4). Futermestotug is promising for research of various malignant tumors [1].
    Futermestotug
  • HY-P992099
    Afivastobart

    AB598

    		 NTPDase Cancer
    Afivastobart (AB598) is a human ENTPD1 (CD39)-targeting monoclonal antibody with antineoplastic activity.Afivastobart binds as a monoclonal antibody to modulate Homo sapiens ENTPD1 activity.Afivastobart constitutes a glycoform alfa immunoglobulin G1-kappa monoclonal antibody [1].
    Afivastobart
  • HY-P992105
    Corveldebart

    		ANGPTL Inflammation/Immunology
    Corveldebart is a monoclonal antibody of immunoglobulin G1-kappa that targets ANGPTL4. Corveldebart can be used as an immunomodulator [1].
    Corveldebart
  • HY-P992394
    JNJ-55920839

    CNTO-6358

    		 IFNAR Inflammation/Immunology
    JNJ-55920839 (CNTO-6358) is a fully human immunoglobulin G1κ monoclonal antibody and a selective Interferon α/ω neutralizer, with a Kd value of 0.9-10.7 pM against hIFNα and a Kd of 1.44 pM against IFNω. JNJ-55920839 can be used in research related to systemic lupus erythematosus [1] .
    JNJ-55920839
  • HY-P992113
    Evabosmig

    		β-catenin Wnt Metabolic Disease
    Evabosmig is a multispecific antibody targeting SOST, DKK-1 and ALB. Evabosmig can be used for the study of osteoporosis [1].
    Evabosmig

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