2 Results for "

GLI1-DNA

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "GLI1-DNA" in MCE Product Catalog:

Cat. No.: HY-122590
CAS No.: 65893-94-9
Purity:  98.05%
Target:  

Gli

Research Areas:  

Cancer

Glabrescione B is the first compound that binds the Hedgehog (Hh) modulator Gli1. Glabrescione B impairs its activity by interfering with Gli1-DNA interaction. Glabrescione B inhibits the growth of Hedgehog-dependent tumor cells, the self-renewal ability, and clonogenicity of tumor-derived stem cells [1] .
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Cat. No.: HY-N8270
CAS No.: 70241-09-7
Physalin H is a natural product that can be isolated from Solanum nigrum. Physalin H is an inhibitor of Hedgehog (Hh) signaling and it disrupts GLI1-DNA-complex formation. Physalin H inhibits GLI1 transcription with an IC50 value of 0.7 μM. Physalin H shows cytotoxicity to PANC1 and DU145 cells with IC50 values of 5.7 and 6.8 μM, respectively [1].
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