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GZMK

" in MedChemExpress (MCE) Product Catalog:

By Targets:	PAI-1 (2) Reference Standards (1) Small Interfering RNA (siRNA) (3) Thrombin (2)
By Research Areas:	Cancer (1) Inflammation/Immunology (1)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Inhibitors & Agonists

Peptides

Recombinant Proteins

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-122542

PPACK	PAI-1 Thrombin	Inflammation/Immunology
PPACK is a potent, peptidic inhibitor targeting thrombin and granzyme *GZMK. PPACK specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1* cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases .

HY-RS26791

Gzmk Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gzmk Rat Pre-designed siRNA Set A contains three designed siRNAs for Gzmk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gzmk Rat Pre-designed siRNA Set A Gzmk Rat Pre-designed siRNA Set A

HY-RS05942

GZMK Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
GZMK Human Pre-designed siRNA Set A contains three designed siRNAs for GZMK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

GZMK Human Pre-designed siRNA Set A GZMK Human Pre-designed siRNA Set A

HY-108292R

Propacetamol hydrochloride (Standard)	Reference Standards PAI-1 Thrombin	Cancer
Propacetamol (hydrochloride) (Standard) is the analytical standard of Propacetamol (hydrochloride). This product is intended for research and analytical applications. Propacetamol hydrochloride is a potent, peptidic inhibitor targeting thrombin and granzyme *GZMK. Propacetamol hydrochloride specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1* cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, Propacetamol hydrochloride exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. Propacetamol hydrochloride binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. Propacetamol hydrochloride is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases .

HY-RS20283

Gzmk Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Gzmk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gzmk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gzmk Mouse Pre-designed siRNA Set A Gzmk Mouse Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-122542

PPACK	PAI-1 Thrombin	Inflammation/Immunology
PPACK is a potent, peptidic inhibitor targeting thrombin and granzyme *GZMK. PPACK specifically blocks the activities of thrombin and GZMK, thereby inhibiting thrombin-mediated PAR-1* cleavage, as well as downstream inflammatory and procoagulant signaling pathways. Through stabilizing IκB proteins, blocking NF-κB activation and reducing systemic levels of proinflammatory/procoagulant biomarkers, PPACK exerts multiple effects including anti-inflammatory, antithrombotic, barrier repair, and inhibition of atherosclerotic plaque progression. PPACK binds to platelets without interference from kininogen, effectively limiting acute thrombus growth and reducing eosinophil infiltration and goblet cell hyperplasia in asthma models. PPACK is an important tool molecule for investigating the mechanisms of atherosclerosis, asthma and related thromboinflammatory diseases .

Species:	Human (1) Mouse (1)
Tag:	His (2) Myc (1)
Source:	E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P702811

	Granzyme K Protein, Human (His) Fragmentin-3; Granzyme-3; NK-tryptase-2 (NK-Tryp-2); GZMK	Human	E. coli
	Granzyme K is a serine protease. Granzyme K can degrade cellular proteins once introduced into a target cell's cytoplasm leading to apoptosis. Granzyme K shows significant connections to inflammatory conditions and autoimmune diseases such as rheumatoid arthritis. Granzyme K Protein, Human (His) is the recombinant human-derived Granzyme K, expressed by E. coli , with N-6*His labeled tag.

HY-P702812

	Granzyme K Protein, Mouse (His, Myc) Fragmentin-3; Granzyme-3; NK-tryptase-2 (NK-Tryp-2); GZMK	Mouse	E. coli
	Granzyme K Protein, Mouse (His, Myc) is the recombinant mouse-derived Granzyme K, expressed by E. coli , with C-Myc, N-10*His labeled tag.

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Host:	Mouse (2)
Reactivity:	Human (2)
Application:	IHC-P (2) FC (2) ELISA (2)
Isotype:	IgG2b (2)
Conjugation:	Non-conjugated (2)
Clonality:	Monoclonal Antibody (1)
Modification:	Unmodified (1)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P84360

	GZMK Antibody (YA4057) TRYP2	IHC-P, FC, ELISA	Human
	GZMK Antibody (YA4057) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GZMK.

HY-P84360A

	GZMK Antibody (YA4057)(PBS only) TRYP2	IHC-P, FC, ELISA	Human
	GZMK Antibody (YA4057) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to GZMK.

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Size	* This product has been "discontinued". Optimized version of product available: / In-stock - + Add to Cart Get quote

Gzmk Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Gzmk Rat Pre-designed siRNA Set A contains three designed siRNAs for Gzmk gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

GZMK Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
GZMK Human Pre-designed siRNA Set A contains three designed siRNAs for GZMK gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Gzmk Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Gzmk Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gzmk gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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