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Pathways Recommended: Metabolic Enzyme/Protease
Results for "

HIV type-1 protease

" in MedChemExpress (MCE) Product Catalog:
Targets Recommended:
製品番号 製品名 Target 研究分野 構造式
  • HY-107123
    TMC310911
    1 Publications Verification

    ASC-09

    		 HIV Protease Infection
    TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity .
    TMC310911
  • HY-106395
    Telinavir

    SC-52151

    		 HIV Protease HIV Infection
    Telinavir (SC-52151) is a potent and selective HIV protease inhibitor. Telinavir inhibits lymphotropic, monocytotropic strains and field isolates of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus with EC50s of 26 ng/mL (43 nM). Telinavir is highly protein bound in human plasma and exhibits low partitioning into erythrocytes .
    Telinavir
  • HY-106395A
    (Rac)-Telinavir

    (Rac)-SC-52151

    		 HIV Protease HIV Infection
    (Rac)-Telinavir ((Rac)-SC-52151) is a racemate of Telinavir (HY-106395A). Telinavir (SC-52151) is a potent and selective HIV protease inhibitor. Telinavir inhibits lymphotropic, monocytotropic strains and field isolates of HIV type 1 (HIV-1), HIV-2, and simian immunodeficiency virus with EC50s of 26 ng/mL (43 nM). Telinavir is highly protein bound in human plasma and exhibits low partitioning into erythrocytes .
    (Rac)-Telinavir
  • HY-19194
    A-80987

    		HIV Protease Infection
    A-80987 is an inhibitor of human immunodeficiency virus type 1 (HIV-1) protease .
    A-80987
  • HY-117747
    DMP 323

    JCR 424; XM 323

    		 HIV Protease Infection
    DMP 323 is a potent, nonpeptide cyclic urea inhibitor of HIV protease, effective against both HIV type 1 and type 2. Designed using structural information and database searching, it competitively inhibits the cleavage of both peptide and HIV-1 gag polyprotein substrates. DMP 323 shows comparable potency to other highly effective HIV protease inhibitors like A-80987 and Ro-31-8959. Importantly, its efficacy against HIV protease remains unaffected by human plasma or serum, suggesting low affinity for plasma proteins. Furthermore, DMP 323 demonstrates minimal inhibition of various mammalian proteases at concentrations much higher than those needed for HIV protease inhibition, highlighting its specificity for viral targets .
    DMP 323
  • HY-139794
    SDZ283-910

    		HIV Infection
    SDZ283-910 is a potent human immunodeficiency virus type-1 (HIV-1) protease inhibitor .
    SDZ283-910
  • HY-161270
    HIV-1 protease-IN-13

    		HIV Protease Infection
    HIV-1 protease-IN-13 (compound 18d) is a potent HIV-1 protease inhibitor with an IC50 value of 0.54 nM. HIV-1 protease-IN-13 also shows potent activity against HIV-1DRVRS (DRV-resistant mutation) and HIV-1NL4_3 variant (wild type) .
    HIV-1 protease-IN-13
  • HY-125494
    Droxinavir hydrochloride

    SC-55389A

    		 HIV HIV Protease Infection
    Droxinavir hydrochloride (SC-55389A) is an HIV-1 protease inhibitor. Droxinavir hydrochloride binds to the S2 and S2' subsites of HIV-1 protease, and this interaction is regulated by protease amino acid residue 88, where the N88S mutation confers viral resistance. Droxinavir hydrochloride can be used in studies related to human immunodeficiency virus type 1 infection .
    Droxinavir hydrochloride
  • HY-122453
    Palinavir

    		HIV Protease Infection
    Palinavir is a potent human immunodeficiency virus type 1 (HIV-1) and type 2 (HIV-2) protease inhibitor with an IC50 of 0.5-30 nM . Palinavir has antiviral activity .
    Palinavir
  • HY-107123R
    TMC310911 (Standard)

    ASC-09 (Standard)

    		 Reference Standards HIV Protease Infection
    TMC310911 (Standard) (ASC-09 (Standard)) is the analytical standard of TMC310911 (HY-107123). This product is intended for research and analytical applications. TMC310911 is a potent and orally active HIV type-1 (HIV-1) protease inhibitor with EC50 values ranged from 2.2 nM to 14.2 nM for wild-type HIV-1. TMC310911 has potent activity against a wide spectrum of recombinant HIV-1 isolates. TMC310911 has strong antiviral activity .
    TMC310911 (Standard)
  • HY-183562
    TMC-126

    UIC-94003

    		 HIV HIV Protease Infection
    TMC-126 (UIC-94003) is a non-peptidic HIV-1 protease (HIV-1 protease) inhibitor. TMC-126 exhibits highly potent antiproliferative activity against wild-type HIV-1. TMC-126 can be used in studies related to HIV infection [1] .
    TMC-126
  • HY-182316
    P-1946

    		HIV Protease HIV Infection
    P-1946 is a HIV protease inhibitor with a human HIV-1 protease Ki of 2.600 nM. P-1946 has potent and selective in vitro antiviral activity and retains full antiviral activity against HIV isolates resistant to commercially available protease inhibitors. P-1946 can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection .
    P-1946
  • HY-125494A
    Droxinavir

    SC-55389A free base

    		 HIV HIV Protease Infection
    Droxinavir (SC-55389A free base) is an HIV-1 protease inhibitor. Droxinavir binds to the S2 and S2' subsites of HIV-1 protease, and this interaction is regulated by protease amino acid residue 88, where the N88S mutation confers viral resistance. Droxinavir can be used in studies related to human immunodeficiency virus type 1 infection .
    Droxinavir
  • HY-126120
    BILA 1906 BS

    		HIV HIV Protease Infection
    BILA 1906 BS is a HIV protease inhibitor. BILA 1906 BS prevents HIV-1 replication via inhibition of viral protease-mediated cleavage of Gag and Gag-Pol polyprotein precursors during virion maturation. BILA 1906 BS blocks maturation of p24 proteins in wild-type HIV-1, impairing polyprotein processing and viral maturation. BILA 1906 BS can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection .
    BILA 1906 BS

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