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Cat. No.: HY-183562

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TMC-126

(Synonyms: UIC-94003)

TMC-126 (UIC-94003) is a non-peptidic HIV-1 protease (HIV-1 protease) inhibitor. TMC-126 exhibits highly potent antiproliferative activity against wild-type HIV-1. TMC-126 can be used in studies related to HIV infection^[1].

For research use only. We do not sell to patients.

CAS No.: 253265-95-1
Formula: C₂₈H₃₈N₂O₈S
Molecular Weight:562.67

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

TMC-126 Chemical Structure

CAS No.: 253265-95-1

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Biological Activity
- Description
- In Vitro
Chemical Information
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Bioz

Biological Activity

Description

All HIV Isoforms :

In Vitro

TMC-126 exhibits potent inhibitory activity against multiple wild-type HIV-1 strains, with an IC₅₀ ranging from 0.3 to 0.5 nM. It also maintains potent inhibitory effects against 8 clinical isolates with multiple PI resistance, showing an IC₅₀ of 0.5 to 5.5 nM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 253265-95-1
Molecular Weight 562.67
Formula C₂₈H₃₈N₂O₈S
SMILES

O=S(C1=CC=C(OC)C=C1)(N(C[C@@H](O)[C@@H](NC(O[C@@H]2CO[C@H]3[C@@H]2CCO3)=O)CC4=CC=CC=C4)CC(C)C)=O
Synonyms

UIC-94003
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Affram KA, et al. Asymmetric Synthesis of the HIV Protease Inhibitor TMC-126, a PMX Antimalarial Protease Inhibitor, and a Putative COVID-19 Inhibitor Using a Highly Stereoselective Glycolate Aldol Addition Reaction Pathway. ACS Omega. 2026;11(18):27331-27341. Published 2026 May 1. [Content Brief]

[2]. Yoshimura K, et al. A potent human immunodeficiency virus type 1 protease inhibitor, UIC-94003 (TMC-126), and selection of a novel (A28S) mutation in the protease active site. J Virol. 2002 Feb;76(3):1349-58.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
References

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TMC-126

All HIV Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

TMC-126 Related Classifications

HY-183562 Related Classifications