BILA 1906 BS 

BILA 1906 BS is a HIV protease inhibitor. BILA 1906 BS prevents HIV-1 replication via inhibition of viral protease-mediated cleavage of Gag and Gag-Pol polyprotein precursors during virion maturation. BILA 1906 BS blocks maturation of p24 proteins in wild-type HIV-1, impairing polyprotein processing and viral maturation. BILA 1906 BS can be used for the research of human immunodeficiency virus type 1 (HIV-1) infection^[1].

BILA 1906 BS (serial twofold dilutions; 3 days) inhibits wild-type HIV-1 replication in acutely infected C8166 T cells with an EC₅₀ of 1 nM^[1].
BILA 1906 BS inhibits wild-type HIV-1 protease with a K_i of 1.7 pM, and protease mutations selected by BILA 1906 BS reduce inhibitor binding, with the HIV-1^{V32I M46I A71V I84A} mutant showing a 12,000-fold increase in K_i^[1].
BILA 1906 BS (0-1000 nM; 3 days) blocks polyprotein processing in wild-type HIV-1 particles from transfected 293 cells, but has minimal effect on processing in highly resistant HIV-1 clones bearing protease mutations V32I, M46I, A71V, I84A and a p1/p6 cleavage site mutation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

724.95

C₄₁H₅₂N₆O₄S

154612-31-4

O=C(N[C@@H](C(C)C)C(N[C@H]([C@@H](CN1[C@@H](C[C@@H](CC1)SCC2=CC=CN=C2)C(NC(C)(C)C)=O)O)CC3=CC=CC=C3)=O)C4=NC5=CC=CC=C5C=C4

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Croteau G, et al. Impaired fitness of human immunodeficiency virus type 1 variants with high-level resistance to protease inhibitors. J Virol. 1997;71(2):1089-1096.  [Content Brief]