3 Results for "

HSV-TK

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "HSV-TK" in MCE Product Catalog:

Cat. No.: HY-126218
CAS No.: 111687-37-7
Target:  

HSV

연구분야:  

Cancer

HSV-TK substrate is a substrate for HSV-TK, and induces multi-log cytotoxicity in HSV-TK-expressing and bystander cells. HSV-TK substrate shows antitumor activity .
loading...
    loading...
Cat. No.: HY-104083
CAS No.: 156126-12-4
Synonyms: N-MCT
Target:  

DNA/RNA Synthesis HSV

연구분야:  

Infection Cancer

North-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk .
loading...
    loading...
Cat. No.: HY-183390
CAS No.: 136565-26-9
Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor. By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1, c-myc, and survivin; it also upregulates DR4/DR5 and downregulates Bcl-2, thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK, and can inactivate HSV-1. It shows synergistic antiviral effects when combined with Acyclovir (HY-17422) or Ganciclovir (HY-13637), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer, cervical cancer, glioblastoma, and digestive system cancers .
loading...
    loading...