136565-26-9
Chemical Structure
Scopadulciol
- CAS No.: 136565-26-9
- Formula:C27H36O4
- Molecular Weight:424.57
InChIKey: CFPMRJFTBKYCRR-FOOPCEIZSA-N
SMILES: C[C@@]12[C@]34[C@@](CC([C@](C3)(CC4)C)=O)([H])C[C@H]([C@@]1([H])[C@@](C)(CCC2)CO)OC(C5=CC=CC=C5)=O
Biological Activity: Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor. By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1, c-myc, and survivin; it also upregulates DR4/DR5 and downregulates Bcl-2, thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK, and can inactivate HSV-1. It shows synergistic antiviral effects when combined with Acyclovir (HY-17422) or Ganciclovir (HY-13637), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer, cervical cancer, glioblastoma, and digestive system cancers[1][2][3][4].
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Scopadulciol | Scopadulciol is an orally effective β-catenin degrader, HSV-TK activator and proton pump inhibitor. By inducing β-catenin degradation, Scopadulciol downregulates the expression of downstream target genes such as cyclin D1, c-myc, and survivin; it also upregulates DR4/DR5 and downregulates Bcl-2, thereby exerting cytotoxicity and inducing apoptosis in cancer cells. Scopadulciol enhances the tumor-killing and bystander effects of prodrugs via activating HSV-TK, and can inactivate HSV-1. It shows synergistic antiviral effects when combined with Acyclovir (HY-17422) or Ganciclovir (HY-13637), with no cytotoxicity as a single agent. Scopadulciol can be applied in research related to bladder cancer, cervical cancer, glioblastoma, and digestive system cancers. | |||||||||||||||||||||
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References
- [1]. Fuentes RG, et al. Scopadulciol, Isolated from Scoparia dulcis, Induces β-Catenin Degradation and Overcomes Tumor Necrosis Factor-Related Apoptosis Ligand Resistance in AGS Human Gastric Adenocarcinoma Cells. Journal of natural products. 2015 Apr 24;78(4):864-72. [Content Brief]
- [2]. Hayashi K, et al. The role of a HSV thymidine kinase stimulating substance, scopadulciol, in improving the efficacy of cancer gene therapy. The journal of gene medicine. 2006 Aug;8(8):1056-67. [Content Brief]
- [3]. Hayashi T, et al. Scopadulciol, an inhibitor of gastric H+, K(+)-ATPase from Scoparia dulcis, and its structure-activity relationships. Journal of natural products. 1991;54(3):802-9. [Content Brief]
- [4]. Hayashi T, et al. [Studies on evaluation of natural products for antiviral effects and their applications]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 2008 Jan;128(1):61-79. [Content Brief]
