North-methanocarbathymidine (Synonyms: N-MCT)

Cat. No.: HY-104083: Data Sheet Handling Instructions
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North-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk.

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North-methanocarbathymidine Chemical Structure

CAS No. : 156126-12-4

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HSV-1 HSV-2 HSV

Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target^[1]

HSV-1

HSV-2

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	> 396 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by CPE assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by CPE assay	[PMID: 14584954]
HFF	CC₅₀	> 396 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by CPE assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by CPE assay	[PMID: 14584954]
HFF	CC₅₀	> 79 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by VPR assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by VPR assay	[PMID: 14584954]
HFF	CC₅₀	> 79 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by VPR assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by VPR assay	[PMID: 14584954]
HFF	EC₅₀	0.04 μM Compound: 1a	Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.12 μM Compound: 1a	Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.35 μM Compound: 1a	Inhibitory concentration required to reduce HSV-2 induced cytopathogenic effect (CPE) by 50 % in HFF cells Inhibitory concentration required to reduce HSV-2 induced cytopathogenic effect (CPE) by 50 % in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.47 μM Compound: 1a	Inhibitory concentration for HSV-2 plaque reduction (VPR) by 50% in HFF cells Inhibitory concentration for HSV-2 plaque reduction (VPR) by 50% in HFF cells	[PMID: 14584954]

Molecular Weight

252.27

Formula

C₁₂H₁₆N₂O₄

CAS No.

156126-12-4

SMILES

O=C1NC(C(C)=CN1[C@@H]2[C@@]3([H])C[C@@]3(CO)[C@@H](O)C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Marquez VE, et al. The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent. Antiviral Res. 2006 Sep;71(2-3):268-75. [Content Brief]

North-methanocarbathymidine Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

North-methanocarbathymidine156126-12-4N-MCTDNA/RNA SynthesisHSVHerpes simplex virusantiviralanticancerMC38KSHVInhibitorinhibitorinhibit

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