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Cat. No.: HY-104083

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North-methanocarbathymidine

(Synonyms: N-MCT)

North-methanocarbathymidine (N-MCT) is a potent antiviral agent. North-methanocarbathymidine inhibits DNA synthesis. North-methanocarbathymidine demonstrates potent antiviral activity against HSV-1, HSV-2 and KSHV. North-methanocarbathymidine exhibits anticancer activity against colon adenocarcinoma expressing HSV-tk.

For research use only. We do not sell to patients.

CAS No.: 156126-12-4
Formula: C₁₂H₁₆N₂O₄
Molecular Weight:252.27

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (272 KB)

North-methanocarbathymidine Chemical Structure

CAS No.: 156126-12-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

HSV-1

HSV-2

All DNA/RNA Synthesis Isoforms :

All HSV Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
HFF	CC₅₀	>396 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by CPE assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by CPE assay	[PMID: 14584954]
HFF	CC₅₀	>396 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by CPE assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by CPE assay	[PMID: 14584954]
HFF	CC₅₀	>79 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by VPR assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-1 infected HFF cells determined by VPR assay	[PMID: 14584954]
HFF	CC₅₀	>79 μM Compound: 1a	Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by VPR assay Cytotoxic concentration for 50% inhibition of cell growth of HSV-2 infected HFF cells determined by VPR assay	[PMID: 14584954]
HFF	EC₅₀	0.04 μM Compound: 1a	Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells Inhibitory concentration for HSV-1 plaque reduction (VPR) by 50% in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.12 μM Compound: 1a	Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells Inhibitory concentration required to reduce HSV-1 induced cytopathogenic effect (CPE) by 50 % in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.35 μM Compound: 1a	Inhibitory concentration required to reduce HSV-2 induced cytopathogenic effect (CPE) by 50 % in HFF cells Inhibitory concentration required to reduce HSV-2 induced cytopathogenic effect (CPE) by 50 % in HFF cells	[PMID: 14584954]
HFF	EC₅₀	0.47 μM Compound: 1a	Inhibitory concentration for HSV-2 plaque reduction (VPR) by 50% in HFF cells Inhibitory concentration for HSV-2 plaque reduction (VPR) by 50% in HFF cells	[PMID: 14584954]

Chemical Information

CAS No. 156126-12-4
Molecular Weight 252.27
Formula C₁₂H₁₆N₂O₄
SMILES

O=C1NC(C(C)=CN1[C@@H]2[C@@]3([H])C[C@@]3(CO)[C@@H](O)C2)=O
Synonyms

N-MCT
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (272 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Marquez VE, et al. The history of N-methanocarbathymidine: the investigation of a conformational concept leads to the discovery of a potent and selective nucleoside antiviral agent. Antiviral Res. 2006 Sep;71(2-3):268-75. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biological Activity
- Description
- IC₅₀ & Target
Chemical Information
Purity & Documentation
References

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North-methanocarbathymidine

All DNA/RNA Synthesis Isoforms

All HSV Isoforms