11 Results for "

Hirudin

" in MedChemExpress (MCE) Product Catalog:
Products (11)

11 Results for "Hirudin" in MCE Product Catalog:

4
4 Cited Publications
Cat. No.: HY-P2813
CAS No.: 8001-27-2
Hirudin is a thrombin inhibitor with blood anticoagulant property. Hirudin has potent anti-thrombotic, wound repair, anti-fibrosis, anti-tumor and anti-hyperuricemia effects. Hirudin also affects diabetic complications, cerebral hemorrhage, and others .
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10
10 Publications Verification
Cat. No.: HY-P1929
CAS No.: 128270-60-0
Bivalirudin, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin can be used for the research of thrombotic diseases and others .
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10 Publications Verification
Cat. No.: HY-15664
CAS No.: 1191386-55-6
Purity:  99.89%
Bivalirudin TFA, a hirudin analog and anticoagulant, is a direct thrombin inhibitor. Bivalirudin TFA inhibits thrombin-mediated fibrinogen cleavage, coagulation factor activation, and platelet activation by reversibly binding to thrombin. In addition, Bivalirudin TFA also has certain effects of anti-virus, anti-inflammation, and vascular endothelial barrier function protection. Bivalirudin TFA can be used for the research of thrombotic diseases and others .
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Cat. No.: HY-P1636
CAS No.: 113274-56-9
Research Areas:  

Metabolic Disease

Hirudin (54-65) is a thrombin antagonist and YAP suppressor with anticoagulatory properties.Hirudin (54-65) blocks thrombin's anion binding site, acts on soluble and thrombus-bound thrombin.Hirudin (54-65) suppresses thrombin-induced profibrotic YAP activity, reduces YAP expression, nuclear translocation, and downstream effector signaling in vascular endothelial cells.Hirudin (54-65) ameliorates obstructive cholestasis, attenuates liver fibrosis symptoms, fibrosis-associated angiogenesis, and endothelial-to-mesenchymal transition.Hirudin (54-65) reduces liver inflammation and tissue hypoxia.Hirudin (54-65) promotes extracellular calcium influx through L-type calcium channels in canine coronary artery smooth muscle, mediates contraction.Hirudin (54-65) induces endothelium-independent contraction of canine coronary arterial segments; this response is not affected by indomethacin pretreatment.Hirudin (54-65) can be used for the research of liver obstructive cholestasis, liver fibrosis .
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Cat. No.: HY-P4325
CAS No.: 109528-50-9
Target:  

Thrombin

Research Areas:  

Others

Hirudin (55-65) (sulfated) is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property.
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Cat. No.: HY-P1636A
Target:  

Thrombin

Research Areas:  

Cardiovascular Disease

Hirudin (54-65) TFA is a fragment of Hirudin with anticoagulant effects. Hirudin is a thrombin inhibitor with blood anticoagulant property .
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Cat. No.: HY-P4795
CAS No.: 125441-01-2
Target:  

Thrombin

Research Areas:  

Others

Acetyl-Hirudin (55-65) (sulfated) is a Acetyl-fragment of Hirudin. Hirudin is a thrombin inhibitor with blood anticoagulant property .
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Cat. No.: HY-P2023
CAS No.: 121822-23-9
Target:  

Drug Derivative

Research Areas:  

Others

Hirugen is a derivative of hirudin, an anticoagulant protein found in leeches .
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Cat. No.: HY-P4721
CAS No.: 131791-98-5
Target:  

Thrombin

Research Areas:  

Cardiovascular Disease

Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is a hirugen-like peptide, and has high affnity for thrombin than Hirugen, with a KD < 100 nM. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) is an antithrombotic agent. Succinyl-(Pro58,D-Glu65)-Hirudin (56-65) (sulfated) inhibits the thrombin-induced fibrin clot formation with an IC50 value of 0.087 μM .
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Cat. No.: HY-P2490
CAS No.: 125441-00-1
Target:  

Thrombin

Research Areas:  

Metabolic Disease

Acetyl-Hirudin (54-65) (sulfated) is a acetyl-fragment of Hirudin which binds directly to thrombin-rHCII(L444R) and disrupts interactions between the N-terminal acidic domain of rHCII and anion-binding exosite I of thrombin that serves to stabilize the complex .
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Cat. No.: HY-P72799
Purity:  ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: Hirudin
Species:  
Source:  
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