7 Results for "

IETDC

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "IETDC" in MCE Product Catalog:

Cat. No.: HY-120833
CAS No.: 219138-21-3
Purity:  99.90%
Target:  

Caspase

Research Areas:  

Others

Ac-Ile-Glu-Thr-Asp-pNA is a substrate for caspase-8. Caspase-8 binds to and cleaves the Ile-Glu-Thr-Asp (IETD) peptide sequence to release p-nitroalinide, which can be quantified by colorimetric detection at 405 nm as a measure of enzyme activity .
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Cat. No.: HY-P10322
Target:  

Fluorescent Dye

Research Areas:  

Cancer

Z-IETD-R110 is a fluorescent substrate of caspases. Z-IETD-R110 acts as a substrate for caspase-8. When caspase-8 is activated, it can recognize and cut Z-IETD-R110, releasing fluorophore, which can be detected by fluorescence microscopy. Z-IETD-R110 can be used to study oxidative stress-induced apoptosis, particularly in pancreatic acinar cells .
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Cat. No.: HY-D3169
CAS No.: 1476735-95-1
Target:  

Fluorescent Dye Caspase

Research Areas:  

Inflammation/Immunology

IETDC is a caspase 8-responsive fluorescent probe. IETDC is cleaved by activated caspase 8 to release D-cysteine, which then reacts with 6-hydroxy-2-cyanobenzothiazole (HCBT) ​​to form firefly luciferin in situ. IETDC must be used in conjunction with PCL-2 (HY-D3168) to detect the co-existence of hydrogen peroxide and caspase 8. IETDC is applicable to studies related to acute inflammation .
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Cat. No.: HY-P1169A
Target:  

Caspase

Research Areas:  

Others

Ac-IETD-AFC TFA is a synthetic fluorogenic substrate that can be used to specifically detect caspase-8 activity. INDO 1 pentasodium is imbued with the fluorophore AFC (7-amino-4-trifluoromethylcoumarin). When caspase-8 recognizes and cleaves the amide bond following the IETD sequence in this substrate, AFC is released and emits fluorescence (Ex = ~400 nm; Em = ~505 nm) .
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Cat. No.: HY-P10001
CAS No.: 348079-18-5
Synonyms: Z-Ile-Glu-Thr-Asp-pNA
Target:  

Caspase

Research Areas:  

Cancer

Z-IETD-pNA (Z-Ile-Glu-Thr-Asp-pNA) is a colorimetric caspase-8 and granzyme B substrate. Z-IETD-pNA is hydrlyzed by caspase 8 to generate pNA .
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Cat. No.: HY-175057
Target:  

Apoptosis

Research Areas:  

Inflammation/Immunology Cancer

Ac-IETD-CHO TFA is a potent, reversible inhibitor of granzyme B and caspase-8. Ac-IETD-CHO TFA inhibits Fas-mediated apoptotic cell death, hemorrhage, and liver failure. Ac-IETD-CHO TFA also inhibits cytotoxic T lymphocytes induced cell death .
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Cat. No.: HY-D3168
CAS No.: 1421277-81-7
PCL-2 is a reactive oxygen species (ROS)-responsive fluorescent probe. PCL-2 reacts with ROS to release 6-hydroxy-2-cyanobenzothiazole (HCBT), which then reacts with D-cysteine ​​to form firefly luciferin in situ. PCL-2 must be used in conjunction with IETDC (HY-D3169) to detect the co-existence of hydrogen peroxide and caspase 8. PCL-2 is applicable to studies related to acute inflammation .
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