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Results for "

Langerin

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Calcium Channel (1)
By Research Areas:	Inflammation/Immunology (1)

Inhibitors & Agonists

Recombinant Proteins

Antibodies

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W069974

*Ca2+ -Langerin-IN-1*	Calcium Channel	Inflammation/Immunology
Ca2+-Langerin-IN-1 (Compound 3) is a allosteric *Langerin* inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The K_D value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy .

Recombinant Proteins Recommended:

Langerin

Species:	Human (1) Rhesus Macaque (1) Mouse (1)
Tag:	His (2) Fc (1)
Source:	HEK293 (2) E. coli (1)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P71602

	Langerin/CD207 Protein, Mouse (His) Cd207; Clec4kC-type lectin domain family 4 member K; Langerin; CD antigen CD207	Mouse	E. coli
	Langerin, also known as CD207, is a calcium-dependent lectin with mannose-binding specificity. Notably, it induces the formation of Birbeck granules (BG) and acts as an effective regulator of membrane stacking and zipping. Langerin/CD207 Protein, Mouse (His) is the recombinant mouse-derived Langerin/CD207 protein, expressed by E. coli , with N-His labeled tag.

HY-P7819

	Langerin/CD207 Protein, Human (HEK293, His) rHuC-type lectin domain family 4 member K/CD207, His; CD207 antigen; Langerin; CD207; C-type lectin domain family 4 member K; C-type lectin domain family 4, member K	Human	HEK293
	CLC4K protein, a calcium-dependent lectin, promotes antigen uptake. CLC4K is able to bind to sulfated as well as mannosylated glycans, keratan sulfate (KS), and β-glucan. Langerin/CD207 Protein, Human (HEK293, His) is the recombinant human-derived Langerin/CD207 protein, expressed by HEK293 , with N-6*His labeled tag.

HY-P77437

	Langerin/CD207 Protein, Rhesus Macaque (HEK293, Fc) C-type lectin domain family 4 member K; CLEC4K	Rhesus Macaque	HEK293
	Langerin, also known as CD207, is a calcium-dependent lectin with mannose-binding specificity. Notably, it induces the formation of Birbeck granules (BG) and acts as an effective regulator of membrane stacking and zipping. Langerin/CD207 Protein, Rhesus Macaque (HEK293, Fc) is the recombinant Rhesus Macaque-derived Langerin/CD207 protein, expressed by HEK293 , with N-hFc labeled tag.

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Host:	Rabbit (3)
Reactivity:	Human (3)
Application:	IHC-P (3) IF-Tissue (1) IHC-F (1)
Isotype:	IgG (3)
Conjugation:	Non-conjugated (3)
Clonality:	Monoclonal (1) Recombinant (2)
Modification:	Unmodified (2)

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HY-P81521

	Langerin Antibody (YA1266) CD207; CD207 antigen; Langerin; CD207 molecule; CLEC4K; Langerhans cell specific c type lectin; Langerin	IHC-P	Human
	Langerin Antibody (YA1266) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Langerin.

HY-P81521A

	Langerin Antibody (YA1266)(PBS only) CD207; CD207 antigen; Langerin; CD207 molecule; CLEC4K; Langerhans cell specific c type lectin; Langerin	IHC-P	Human
	Langerin Antibody (YA1266) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Langerin.

HY-P87979

	Langerin Antibody (YA7664)	IHC-P, IHC-F, IF-Tissue	Human
	Langerin Antibody (YA7664) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Langerin.

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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