79932-56-2
Chemical Structure
Ca2+ -Langerin-IN-1
- CAS No.: 79932-56-2
- Formula:C9H8N2O3S
- Molecular Weight:224.24
IUPAC Name: 2,3-dimethyl-5-oxo-5H-thiazolo[3,2-a]pyrimidine-6-carboxylic acid
InChIKey: NTILPFUDSBFNQU-UHFFFAOYSA-N
SMILES: O=C1C(C(O)=O)=CN=C2N1C(C)=C(C)S2
Biological Activity: Ca2+-Langerin-IN-1 (Compound 3) is a allosteric Langerin inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The KD value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy[1].
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Ca2+ -Langerin-IN-1 | Ca2+-Langerin-IN-1 (Compound 3) is a allosteric Langerin inhibitor. Langerin is a C-type lectin that is expressed on Langerhans cells and plays a crucial role in pathogen recognition and innate immune activation. The KD value of the CRD domain of murine Langerin protein for Ca2+-Langerin-IN-1 is 17 μM under the presence of Ca²⁺ and 53 μM under the absence of Ca²⁺ competition. Ca2+-Langerin-IN-1 induces conformational changes and competitively replaces Ca²⁺, thereby inhibiting the carbohydrate recognition function of the protein. Ca2+-Langerin-IN-1 can be used in the research of immunomodulatory therapy. | |||||||||||||||||||||
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