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Results for "

MEF2C

" in MedChemExpress (MCE) Product Catalog:

9

Inhibitors & Agonists

3

Antibodies

5

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-120877
    MRT199665

    		MARK Salt-inducible Kinase (SIK) AMPK Apoptosis Cancer
    MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively . MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells [2]. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 .
    MRT199665
  • HY-164288
    TDI-6570

    TDI-006570

    		 Cyclic GMP-AMP Synthase STING Neurological Disease Inflammation/Immunology
    TDI-6570 (TDI-006570) is a blood-brain barrier-permeable, orally active cGAS inhibitor with an IC50 of 1.64 μM. TDI-6570 exhibits high gastrointestinal absorption and a long brain half-life in mice, and shows no toxicity to primary neurons. By inhibiting the cGAS-STING-IFN signaling pathway, TDI-6570 reduces STING levels and the activation of TBK1, blocks double-stranded DNA-induced cGAS activation and downstream interferon-stimulated gene expression, thereby reducing tau protein spread and improving synaptic loss. TDI-6570 reverses memory deficits, increases the amplitude of long-term potentiation, enhances the MEF2C transcriptional network, restores PSD-95 and vGAT punctate structures, and significantly improves cognitive resilience. TDI-6570 can be applied to the research of Alzheimer's disease, Parkinson's disease, systemic lupus erythematosus, as well as various central nervous system and autoimmune diseases [2] .
    TDI-6570
  • HY-RS08311
    MEF2C Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    MEF2C Human Pre-designed siRNA Set A contains three designed siRNAs for MEF2C gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    MEF2C Human Pre-designed siRNA Set A
    MEF2C Human Pre-designed siRNA Set A
  • HY-174583
    Human MEF2C mRNA

    		mRNA Cancer
    Human MEF2C mRNA encodes the human myocyte enhancer factor 2C (MEF2C) protein, a member of the MADS box transcription enhancer factor 2 (MEF2) family. MEF2C has both trans-activating and DNA binding activities and may play a role in maintaining the differentiated state of muscle cells.
    Human MEF2C mRNA
  • HY-174479
    Mouse Mef2c mRNA

    		mRNA Cardiovascular Disease
    Mouse Mef2c mRNA encodes the mouse myocyte enhancer factor 2C (Mef2c) protein, a transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Mef2c controls cardiac morphogenesis and myogenesis, and is also involved in vascular development, neurogenesis and the development of cortical architecture.
    Mouse Mef2c mRNA
  • HY-RS25510
    Mef2c Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Mef2c Rat Pre-designed siRNA Set A contains three designed siRNAs for Mef2c gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mef2c Rat Pre-designed siRNA Set A
    Mef2c Rat Pre-designed siRNA Set A
  • HY-RS19021
    Mef2c Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Mef2c Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mef2c gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Mef2c Mouse Pre-designed siRNA Set A
    Mef2c Mouse Pre-designed siRNA Set A
  • HY-120877A
    (R)-MRT199665

    		MARK Salt-inducible Kinase (SIK) AMPK Apoptosis Cancer
    (R)-MRT199665 is an isomer of MRT199665 (HY-120877). MRT199665 is a potent and ATP-competitive, selective MARK/SIK/AMPK inhibitor with IC50s of 2/2/3/2 nM, 10/10 nM, and 110/12/43 nM for MARK1/MARK2/MARK3/MARK14, AMPKα1/AMPKα2, and SIK1/SIK2/SIK3, respectively. MRT199665 causes apoptosis in MEF2C-activated human acute myeloid leukemias (AML) cells. MRT199665 inhibits the phosphorylation of SIK substrate CRTC3 at S370 [2] .
    (R)-MRT199665
  • HY-170237
    SIK2/3-IN-1

    		Salt-inducible Kinase (SIK) Cancer
    SIK2/3-IN-1 (Compound 7S) is a selectively inhibitory agent of SIK2/3 with oral activity. SIK2/3-IN-1 can significantly inhibit tumor growth (without any body weight loss) in the MV4-11 AML mice CDX model. SIK2/3-IN-1 can be used in the research of MEF2C-dependent acute myeloid leukemia .
    SIK2/3-IN-1

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