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VUT-MK142 

Cat. No.: HY-122610 Purity: 99.70%
Handling Instructions

VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair.

For research use only. We do not sell to patients.

VUT-MK142 Chemical Structure

VUT-MK142 Chemical Structure

CAS No. : 1313491-22-3

Size Price Stock Quantity
5 mg USD 300 In-stock
Estimated Time of Arrival: December 31
10 mg USD 500 In-stock
Estimated Time of Arrival: December 31
25 mg USD 950 In-stock
Estimated Time of Arrival: December 31
50 mg USD 1550 In-stock
Estimated Time of Arrival: December 31
100 mg USD 2350 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

VUT-MK142 is a potent new cardiomyogenic synthetic agent promoting the differentiation of pre-cardiac mesoderm into cardiomyocytes, which may be useful to differentiate stem cells into cardiomyocytes for cardiac repair[1].

In Vitro

VUT-MK142 possesses promising cardiomyogenic effects on various cell types. VUT-MK142 shows a remarkable effect on both P19 and C2C12 cells. Compared to CgC, VUT-MK142-treatment leads to a markedly stronger up-regulation of the expression of ANF[1].
VUT-MK142 (1 μM, 7 day treatment) significantly (p < 0.05) increases the luciferase signal by 3.1 ± 0.3 luciferase (n = 5)-fold in P19 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

298.38

Formula

C₁₇H₂₂N₄O

CAS No.

1313491-22-3

SMILES

COC1=CC=C(NC2=CC(NC3CCCCC3)=NC=N2)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (83.79 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.3514 mL 16.7572 mL 33.5143 mL
5 mM 0.6703 mL 3.3514 mL 6.7029 mL
10 mM 0.3351 mL 1.6757 mL 3.3514 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.5 mg/mL (8.38 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (8.38 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

VUT-MK142OtherscardiomyocytemesodermcardiacrepairInhibitorinhibitorinhibit

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Product Name:
VUT-MK142
Cat. No.:
HY-122610
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