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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
NRL
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "NRL" in MCE Product Catalog:
Cat. No.: HY-162596
CAS No.: 1973494-16-4
Synonyms: BA-1049 free base
Target:
Research Areas:
NRL-1049 (BA-1049 (free base)) is an orally available and selective ROCK2 inhibitor with IC50 values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .
Cat. No.: HY-126432
CAS No.: 1973494-17-5
Synonyms: BA-1049
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Research Areas:
NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury .
Cat. No.: HY-N15829
CAS No.: 397841-89-3
Synonyms: Fluorescein lisicol disodium; NRL972 disodium
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Research Areas:
Cholyl-Lys-fluorescein sodium is a fluorescein-labeled bile acid analog. Cholyl-Lys-fluorescein sodium mimics the physiological hepatobiliary properties of glycocholic acid. Cholyl-Lys-fluorescein sodium is efficiently taken up by the liver and rapidly excreted into bile in intact form in rats. Cholyl-Lys-fluorescein sodium can serve as a liver function assessment agent, bile salt transport probe, and liver-targeted carrier .
Cat. No.: HY-RS16572
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Lcn2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Lcn2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-105047
CAS No.: 140616-46-2
Synonyms: Fluorescein lisicol; NRL972
Cat. No.: HY-RS09575
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NRL Human Pre-designed siRNA Set A contains three designed siRNAs for NRL gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-126432S
Synonyms: (Rac)-BA-1049-d5
Cat. No.: HY-162596A
CAS No.: 863638-93-1
Synonyms: (Rac)-BA-1049
Target:
Research Areas:
(Rac)-NRL-1049 is the racemic mixture of NRL-1049 (BA-1049 (free base)) (HY-162596). NRL-1049 is an orally available and selective ROCK2 inhibitor with IC50 values of 0.59 µM for ROCK2 and 26 µM for ROCK1, respectively. NRL-1049 modulates ROCK signaling, preserves blood-brain barrier integrity, reduces edema, seizures and hemorrhage, and alleviates cerebral cavernous malformation lesion burden. NRL-1049 can be used for the study of acute brain injury, ischemic stroke, and cerebral cavernous malformations .
Cat. No.: HY-RS21286
Target:
Research Areas:
Nrl Mouse Pre-designed siRNA Set A contains three designed siRNAs for Nrl gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27805
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Research Areas:
Nrl Rat Pre-designed siRNA Set A contains three designed siRNAs for Nrl gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
