Fluorescein lisicol (Synonyms: NRL972)

Cat. No.: HY-105047 Purity: 98.14%: Data Sheet
COA

SDS
Handling Instructions
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Fluorescein lisicol is a fluorescent-labelled bile salt and a marker of hepatic biliary transporter function. Fluorescein lisicol can be used for metabolic research.

For research use only. We do not sell to patients.

Fluorescein lisicol Chemical Structure

CAS No. : 140616-46-2

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Description

Fluorescein lisicol is a fluorescent-labelled bile salt and a marker of hepatic biliary transporter function. Fluorescein lisicol can be used for metabolic research^[1].

Clinical Trial

Molecular Weight

926.12

Formula

C₅₁H₆₃N₃O₁₁S

CAS No.

140616-46-2

Appearance

Solid

Color

Orange to red

SMILES

O=C1OC2(C3=CC=C(O)C=C3OC4=CC(O)=CC=C42)C5=CC=C(NC(NCCCC[C@@H](C(O)=O)NC(CC[C@H]([C@]6([H])[C@@]7([C@@]([C@@]8([H])[C@]([C@@]9([C@](C[C@@H](CC9)O)([H])C[C@H]8O)C)([H])C[C@@H]7O)([H])CC6)C)C)=O)=S)C=C51

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (107.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.0798 mL	5.3989 mL	10.7977 mL
5 mM	0.2160 mL	1.0798 mL	2.1595 mL
10 mM	0.1080 mL	0.5399 mL	1.0798 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.14%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (248 KB) HNMR (366 KB) RP-HPLC (267 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. de Mey C, et al. Effects of renal insufficiency on the elimination of fluorescein lisicol (NRL972), an investigational marker of hepatic transporter function. Int J Clin Pharmacol Ther. 2015 Jul;53(7):523-30. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.0798 mL	5.3989 mL	10.7977 mL	26.9943 mL
	5 mM	0.2160 mL	1.0798 mL	2.1595 mL	5.3989 mL
	10 mM	0.1080 mL	0.5399 mL	1.0798 mL	2.6994 mL
	15 mM	0.0720 mL	0.3599 mL	0.7198 mL	1.7996 mL
	20 mM	0.0540 mL	0.2699 mL	0.5399 mL	1.3497 mL
	25 mM	0.0432 mL	0.2160 mL	0.4319 mL	1.0798 mL
	30 mM	0.0360 mL	0.1800 mL	0.3599 mL	0.8998 mL
	40 mM	0.0270 mL	0.1350 mL	0.2699 mL	0.6749 mL
	50 mM	0.0216 mL	0.1080 mL	0.2160 mL	0.5399 mL
	60 mM	0.0180 mL	0.0900 mL	0.1800 mL	0.4499 mL
	80 mM	0.0135 mL	0.0675 mL	0.1350 mL	0.3374 mL
	100 mM	0.0108 mL	0.0540 mL	0.1080 mL	0.2699 mL

Fluorescein lisicol Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fluorescein lisicol140616-46-2NRL972NRL 972NRL-972Biochemical Assay Reagentsbile saltfluorescenthepatic biliary transporterInhibitorinhibitorinhibit

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Fluorescein lisicol (Synonyms: NRL972)

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