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Cat. No.: HY-P12010

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Ac-ETDK(myr)-AMC

Ac-ETDK(myr)-AMC is a DLAT-derived ε-N-myristoyllysine peptide substrate for fatty-acid deacylase HDAC11, used in fluorescence-based HDAC11 activity assays. Ac-ETDK(myr)-AMC undergoes cleavage of ε-N-myristoyllysine by HDAC11, followed by trypsin-mediated cleavage of C-terminal lysine to release measurable fluorophore AMC.

For research use only. We do not sell to patients.

CAS No.: 1857308-95-2
Formula: C₄₅H₆₈N₆O₁₃
Molecular Weight:901.05

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Ac-ETDK(myr)-AMC Chemical Structure

CAS No.: 1857308-95-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

IC₅₀ & Target^[1]

HDAC-11

All HDAC Isoforms :

In Vitro

Ac-ETDK(myr)-AMC serves as an efficient ε-N-myristoyllysine substrate for recombinant human HDAC11 in an AMC-based fluorescence activity assay^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1857308-95-2
Molecular Weight 901.05
Formula C₄₅H₆₈N₆O₁₃
SMILES

CC(C1=CC=C(NC([C@H](CCCCNC(CCCCCCCCCCCCC)=O)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)C=C1O2)=CC2=O
Sequence

Ac-Glu-Thr-Asp-Lys(myr)-AMC
Sequence Shortening

Ac-ETDK(myr)-AMC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Schäker-Hübner L, et al. Recommended Tool Compounds: Isoform- and Class-Specific Histone Deacetylase Inhibitors. ACS pharmacology & translational science. 2026 Mar 13;9(3):462-489.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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Ac-ETDK(myr)-AMC

All HDAC Isoforms