1857308-95-2
Chemical Structure
Ac-ETDK(myr)-AMC
- CAS No.: 1857308-95-2
- Formula:C45H68N6O13
- Molecular Weight:901.05
InChIKey: HFYIGGUJLBBOOI-QIASAHBBSA-N
SMILES: CC(C1=CC=C(NC([C@H](CCCCNC(CCCCCCCCCCCCC)=O)NC([C@H](CC(O)=O)NC([C@H]([C@H](O)C)NC([C@@H](NC(C)=O)CCC(O)=O)=O)=O)=O)=O)C=C1O2)=CC2=O
Biological Activity: Ac-ETDK(myr)-AMC is a DLAT-derived ε-N-myristoyllysine peptide substrate for fatty-acid deacylase HDAC11, used in fluorescence-based HDAC11 activity assays. Ac-ETDK(myr)-AMC undergoes cleavage of ε-N-myristoyllysine by HDAC11, followed by trypsin-mediated cleavage of C-terminal lysine to release measurable fluorophore AMC[1].
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Ac-ETDK(myr)-AMC | Ac-ETDK(myr)-AMC is a DLAT-derived ε-N-myristoyllysine peptide substrate for fatty-acid deacylase HDAC11, used in fluorescence-based HDAC11 activity assays. Ac-ETDK(myr)-AMC undergoes cleavage of ε-N-myristoyllysine by HDAC11, followed by trypsin-mediated cleavage of C-terminal lysine to release measurable fluorophore AMC. | |||||||||||||||||||||
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Keywords
