1973494-17-5
1973494-17-5
Chemical Structure
NRL-1049 dihydrochloride
Synonym(s): BA-1049
- CAS No.: 1973494-17-5
- Formula:C16H23Cl2N3O2S
- Molecular Weight:392.34
IUPAC Name: (R)-1-(1-(isoquinolin-5-ylsulfonyl)piperidin-4-yl)ethan-1-amine dihydrochloride
InChIKey: ZGHFCJWOBKWTQK-CURYUGHLSA-N
SMILES: C[C@H](C1CCN(CC1)S(=O)(C2=C3C=CN=CC3=CC=C2)=O)N.Cl.Cl
Biological Activity: NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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NRL-1049 dihydrochloride | 99.20% | NRL-1049 dihydrochloride (BA-1049) is a selective and orally active rho-associated protein kinase 2 (ROCK2) inhibitor with an IC50 of 0.59 μM. NRL-1049 dihydrochloride shows selectivity for ROCK2 is 44 times that of ROCK1 (IC50 = 26 μM). NRL-1049 dihydrochloride can preserve the blood-brain barrier after acute injury. | ||||||||||||||||||||
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(Rac)-NRL-1049-d5 dihydrochloride | (Rac)-NRL-1049-d5 dihydrochloride ((Rac)-BA-1049-d5) is deuterated labeled (Rac)-NRL-1049. | |||||||||||||||||||||
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References
