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Results for "

OGR1/GPR68

" in MedChemExpress (MCE) Product Catalog:

12

Inhibitors & Agonists

1

Natural
Products

1

Isotope-Labeled Compounds

3

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-134494
    MS48107
    2 Publications Verification

    		 GPR68 Neurological Disease
    MS48107 is a potent and selective positive allosteric modulator of G protein-coupled receptor 68 (GPR68). MS48107 is selective for GPR68 over the closely related proton GPCRs, neurotransmitter transporters, and hERG ion channels. MS48107 can readily cross the blood-brain barrier (BBB) in mice [1].
    MS48107
  • HY-154954
    Ogremorphin
    2 Publications Verification

    OGM; GPR68-IN-1; OGM-8345

    		 GPR68 Ferroptosis Inflammation/Immunology Cancer
    Ogremorphin (OGM) is a G protein coupled sensor GPR68 inhibitor with anti-inflammatory and anti-tumor activities. Ogremorphin can inhibit the migration of human melanoma cells and induce ferroptosis in glioblastoma cells [1] .
    Ogremorphin
  • HY-110279
    Ogerin
    2 Publications Verification

    		 GPR68 Neurological Disease
    Ogerin, a chemical probe, is a selective GPR68 positive aliasing modulator (PAM) (pEC50=6.83) with a moderate antagonistic effect on A2A (Ki=220 nM). Ogerin inhibits the fear conditioning reflex in mice and also inhibits TGF-β-induced myofibroblast differentiation of fibroblasts from multiple organ systems. Ogerin can be used in the studies of fibrotic diseases and neurological disorders [1] .
    Ogerin
  • HY-105791
    Sulazepam

    		GABA Receptor Inflammation/Immunology
    Sulazepam, a benzodiazepine, is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist. Sulazepam has anticonvulsive action and has the potential for airway hyperresponsiveness (AHR) research [1] .
    Sulazepam
  • HY-162734
    BRD5075

    		GPR65 Inflammation/Immunology
    BRD5075 is a selective GPR65 activator. BRD5075 enhances GPR65 activity under acidic conditions, promotes Gαs-dependent signaling pathways, including cAMP production and G protein recruitment. BRD5075 regulates the cytokine and chemokine expression network in dendritic cells, and inhibits the expression of pro-inflammatory cytokines and chemokines in a GPR65-dependent manner. BRD5075 is applicable to research related to inflammatory bowel disease [1].
    BRD5075
  • HY-132187
    Sphingosylphosphorylcholine

    		TGF-beta/Smad TRP Channel Apoptosis PAI-1 Cardiovascular Disease Neurological Disease Metabolic Disease Inflammation/Immunology Cancer
    Sphingosylphosphorylcholine is a bioactive lipid and a major component of plasma high-density lipoprotein that binds to OGR1 with a Kd of 33.3 nM. Sphingosylphosphorylcholine triggers delayed phosphorylation of Smad2, upregulates α-SMA expression, and activates TRPM3. Sphingosylphosphorylcholine reduces Apoptosis and upregulates the expression of uPA and its receptor uPA-R. Sphingosylphosphorylcholine exerts anti-apoptotic, anti-cardiac hypertrophy and pro-wound healing effects. Sphingosylphosphorylcholine induces scratching behavior in mice. Sphingosylphosphorylcholine is used in studies related to atopic dermatitis, promyelocytic leukemia, heart failure, myocardial ischemia/reperfusion injury, ovarian cancer, breast cancer, pancreatic cancer, and skin wound healing disorders in genetically impaired healing diabetes [1] .
    Sphingosylphosphorylcholine
  • HY-RS05731
    GPR68 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    GPR68 Human Pre-designed siRNA Set A contains three designed siRNAs for GPR68 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    GPR68 Human Pre-designed siRNA Set A
    GPR68 Human Pre-designed siRNA Set A
  • HY-RS05732
    Gpr68 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gpr68 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Gpr68 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gpr68 Mouse Pre-designed siRNA Set A
    Gpr68 Mouse Pre-designed siRNA Set A
  • HY-RS05733
    Gpr68 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Gpr68 Rat Pre-designed siRNA Set A contains three designed siRNAs for Gpr68 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Gpr68 Rat Pre-designed siRNA Set A
    Gpr68 Rat Pre-designed siRNA Set A
  • HY-181485
    GPR68 antagonist 1

    		GPR68 TNF Receptor Interleukin Related Inflammation/Immunology
    GPR68 antagonist 1 is a GPR68 antagonist with an IC50 of 81 nM. GPR68 antagonist 1 inhibits the mouse GPR68-mediated cAMP signaling pathway with an IC50 of 179 nM. GPR68 antagonist 1 alleviates disease symptoms in a dextran sulfate sodium (DSS) (HY-116282C)-induced mouse model of inflammatory bowel disease. GPR68 antagonist 1 is applicable to research related to inflammatory bowel disease [1].
    GPR68 antagonist 1
  • HY-105791S
    Sulazepam-d5

    		Isotope-Labeled Compounds GPR68 Neurological Disease
    Sulazepam-d5 is a deuterium labeled Sulazepam (HY-105791). Sulazepam is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist [1].
    Sulazepam-d5
  • HY-105791R
    Sulazepam (Standard)

    		Reference Standards Others Inflammation/Immunology
    Sulazepam (Standard) is the analytical standard of Sulazepam (HY-105791). This product is intended for research and analytical applications. Sulazepam, a benzodiazepine, is a selective ovarian cancer G protein-coupled receptor (OGR1) agonist. Sulazepam has anticonvulsive action and has the potential for airway hyperresponsiveness (AHR) research [1] .
    Sulazepam (Standard)

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