52 Results for "

PHFs

" in MedChemExpress (MCE) Product Catalog:
Products (52)

52 Results for "PHFs" in MCE Product Catalog:

3
3 Cited Publications
Cat. No.: HY-13643
CAS No.: 1596-84-5
Purity:  99.79%
Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested .
loading...
    loading...
2
2 Cited Publications
Cat. No.: HY-P1675A
Synonyms: AcPHF6 TFA; Ac-VQIVYK-NH2 TFA
Target:  

Tau Protein

Research Areas:  

Neurological Disease

Acetyl-PHF6 amide TFA (AcPHF6 TFA) is a tau derived hexapeptide.
loading...
    loading...
Cat. No.: HY-P4808
CAS No.: 329897-62-3
Target:  

Amyloid-β Autophagy

Research Areas:  

Neurological Disease

PHF6 (VQIVYK) is a self-assembly sequence capable of initiating the full-length tau protein aggregation and is mapped to the third microtubule-binding repeat region of the tau protein .
loading...
    loading...
Cat. No.: HY-137557
CAS No.: 1565797-16-1
Synonyms: APN1607; PM-PBB3
Target:  

Tau Protein

Research Areas:  

Neurological Disease

Florzolotau (APN1607) is a positron emission tomography (PET) ligand that can be used for the detection of Alzheimer's disease (AD) and other tau proteinopathies. Its binding sites are located in the β-sheet of paired helical filaments (PHFs) and straight filaments (SFs) of tau protein, as well as in the C-shaped cavity of SFs. In addition, APN-1607 binds to intraneuronal inclusions in Alzheimer's disease (AD), primary age-related tauopathy (PART) and posterior cortical atrophy (PCA). Florzolotau shows promise for PET imaging studies of neurological disorders, particularly tau proteinopathies .
loading...
    loading...
Cat. No.: HY-P991373

Target:  

Tau Protein

Research Areas:  

Neurological Disease

APNmAb005 is a human monoclonal antibody (mAb) targeting MAPT/Tau/PHF-tau. APNmAb005 blocks tau seeding in vitro and rescues neuronal loss in rTG4510 mice. APNmAb005 can be used in Alzheimer’s disease (AD) research .
loading...
    loading...
Cat. No.: HY-P4808A
Target:  

Amyloid-β Autophagy

Research Areas:  

Neurological Disease

PHF6 (VQIVYK) TFA is a self-assembly sequence capable of initiating the full-length tau protein aggregation. PHF6 TFA is mapped to the third microtubule-binding repeat region of the tau protein .
loading...
    loading...
Cat. No.: HY-138643
CAS No.: 185351-23-9
Purity:  99.97%
Target:  

Amyloid-β

Research Areas:  

Neurological Disease

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein .
loading...
    loading...
Cat. No.: HY-P4933
CAS No.: 2022995-68-0
Synonyms: Tau-F protein (255-314)
Target:  

Tau Protein

Research Areas:  

Neurological Disease

Tau Peptide (255-314) (Repeat 2 Domain) (human) (Tau-F protein (255-314)) is a polypeptide. Tau Peptide (255-314) (human) is the 255-314 fragment of Tau-F (also known as Tau-4, the 2N4 isoform), a major isoform of the Tau protein. Tau Peptide (255-314) (human) contains two core driving sequences for Tau aggregation, namely PHF6* (275-280, VQIINK) and PHF6 (306-311, VQIVYK), and spans the C-terminal half of repeat domain R1, the entire repeat domain R2, and the N-terminal half of repeat domain R3 within the microtubule-binding region (MTBR).
loading...
    loading...
Cat. No.: HY-P2516
CAS No.: 330456-25-2
Target:  

Tau Protein

Research Areas:  

Neurological Disease

Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's Tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein. Tau Peptide (275-305) specifically coordinates with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), which can induce their conformational changes and significantly promote their pathological accumulation. Tau Peptide (275-305) can be used to study the role of heavy metals in neurodegenerative diseases .
loading...
    loading...
Cat. No.: HY-P4819
CAS No.: 2022956-50-7
Target:  

Peptides

Research Areas:  

Others

Acetyl-PHF4 amide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
loading...
    loading...
Cat. No.: HY-P4822
CAS No.: 1190970-24-1
Target:  

Tau Protein

Research Areas:  

Others

Acetyl-PHF5 amide is an amyloidogenic protein tau peptide. Acetyl-PHF5 amide can polymerization into filamentous structures .
loading...
    loading...
Cat. No.: HY-P4828
CAS No.: 885610-34-4
Target:  

Peptides

Research Areas:  

Others

Acetyl-PHF6YA amide is a polypeptide that can be found by peptide screening. Peptide screening is a research tool that pools active peptides primarily by immunoassay. Peptide screening can be used for protein interaction, functional analysis, epitope screening, especially in the field of agent research and development .
loading...
    loading...
Cat. No.: HY-153608
CAS No.: 1310809-17-6
Purity:  97.60%
Target:  

Histone Demethylase

Research Areas:  

Cancer

JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively .
loading...
    loading...
Cat. No.: HY-13643R
CAS No.: 1596-84-5
Daminozide (Standard) is the analytical standard of Daminozide. This product is intended for research and analytical applications. Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested .
loading...
    loading...
Cat. No.: HY-RS10413
Research Areas:  

Others

PHF1 Human Pre-designed siRNA Set A contains three designed siRNAs for PHF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS10414
Research Areas:  

Others

PHF10 Human Pre-designed siRNA Set A contains three designed siRNAs for PHF10 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS10415
Research Areas:  

Others

PHF11 Human Pre-designed siRNA Set A contains three designed siRNAs for PHF11 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS10416
Research Areas:  

Others

PHF12 Human Pre-designed siRNA Set A contains three designed siRNAs for PHF12 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS10417
Research Areas:  

Others

PHF13 Human Pre-designed siRNA Set A contains three designed siRNAs for PHF13 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...
Cat. No.: HY-RS10418
Research Areas:  

Others

PHF14 Human Pre-designed siRNA Set A contains three designed siRNAs for PHF14 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

loading...
    loading...