2. Epigenetics
  3. Histone Demethylase
  4. JHDM-IN-1

JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively.

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JHDM-IN-1 Chemical Structure

JHDM-IN-1 Chemical Structure

CAS No. : 1310809-17-6

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Based on 1 publication(s) in Google Scholar

JHDM-IN-1 Related Antibodies

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Description

JHDM-IN-1 (Compound 1) is a Jumonji C domain-containing HDMs (JHDM) inhibitor with IC50s of 3.4, 4.3, 5.9, 10 and 43 μM against JMJD2C, JMJD2A, JMJD2E, PHF8 and JMJD3, respectively[1].

IC50 & Target

IC50: 3.4 μM (JMJD2C), 4.3 μM (JMJD2A), 5.9 μM (JMJD2E), 10 μM (PHF8), 22 μM (FIH), 31 μM (PHD3), 43 μM (JMJD3), 54 μM (PHD1), 83 μM (PHD2), 620 μM (LSD1)[1]
In Vitro

JHDM-IN-1 (Compound 1) also inhibits FIH, PHD3, PHD1, PHD2 and LSD1 with IC50s of 22, 31, 54, 83 and 620 μM, respectively[1].
JHDM-IN-1 (0-100 μM) does not inhibit KYSE150 cell growth after treatment for 48 h[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

JHDM-IN-1 Related Antibodies
Molecular Weight

491.54

Formula

C27H29N3O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(/C=C/C(N(O)CCCCNCC(C=C1)=CC=C1COC(NC2=CC=CC3=C2C=CC=C3)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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JHDM-IN-1 Related Classifications

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

JHDM-IN-11310809-17-6Histone DemethylaseFIHPHD3PHD1PHD2LSD1KYSE150Inhibitorinhibitorinhibit

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