1596-84-5
1596-84-5
Chemical Structure
Daminozide
- CAS No.: 1596-84-5
- Formula:C6H12N2O3
- Molecular Weight:160.17
IUPAC Name: 4-(2,2-dimethylhydrazinyl)-4-oxobutanoic acid
InChIKey: NOQGZXFMHARMLW-UHFFFAOYSA-N
SMILES: O=C(NN(C)C)CCC(O)=O
Biological Activity: Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Daminozide | 99.79% | Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested. | ||||||||||||||||||||
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Daminozide (Standard) | 99.69% | Daminozide (Standard) is the analytical standard of Daminozide. This product is intended for research and analytical applications. Daminozide, a plant growth regulator, is a selective inhibitor of the human KDM2/7 histone demethylases, with IC50s of 0.55, 1.5 and 2.1 μM for PHF8, KDM2A, and KIAA1718, respectively. Daminozide has >100-fold selectivity for KDM2/7 subfamily versus other demethylase subfamily members tested. | ||||||||||||||||||||
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Daminozide-d4 | Daminozide-d4 is deuterium labeled Daminozide. | |||||||||||||||||||||
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References
- [1]. Rose NR, Woon EC, Tumber A, Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases. J Med Chem. 2012 Jul 26;55(14):6639-43. [Content Brief]
- [2]. Roy SS, et, al. Exploration of teratogenic and genotoxic effects of fruit ripening retardant Alar (Daminozide) on model organism Drosophila melanogaster. Interdiscip Toxicol. 2018 May;11(1):27-37. [Content Brief]
