1. Neuronal Signaling
  2. Amyloid-β
  3. Cl-NQTrp

Cl-NQTrp 

Cat. No.: HY-138643
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Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein.

For research use only. We do not sell to patients.

Cl-NQTrp Chemical Structure

Cl-NQTrp Chemical Structure

CAS No. : 185351-23-9

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Description

Cl-NQTrp signifcantly disrupts the preformed fbrillar aggregates of Tau-derived PHF6 (VQIVYK) peptide and full-length tau protein[1][2].

In Vitro

Cl-NQTrp efciently disassembled pre-formed PHF6 peptide fbrils[1].
Cl-NQTrp has the potential to induce conformational changes in PHF6 peptide oligomers[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Cl-NQTrp could be a unique potential therapeutic for AD since it targets aggregation of both Aβ and tau[2].
Cl-NQTrp significantly alleviates the shorter life span of htau-expressing flies, leading to 58% viability on day 29[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Virgin females, carrying either the eye GMR -Gal4 driver or the pan-neuronal driver elavc155 -Gal4 on chromosome X, were collected and crossed with males carrying UAS-h tau on the 2nd chromosome or with wild-type Oregon-R (OR) males as a control[2].
Dosage: 0.75 mg/mL.
Administration: Dripped every other day.
Result: Inhibited PHF6 aggregation and ameliorates eye neurodegeneration Drosophila overexpressing the human tau protein (htau).
Molecular Weight

394.81

Formula

C₂₁H₁₅ClN₂O₄

CAS No.
SMILES

ClC(C(C1=C(C=CC=C1)C2=O)=O)=C2N[[email protected]](C(O)=O)CC3=CNC4=C3C=CC=C4

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Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

Cl-NQTrpAmyloid-ββ-amyloid peptideAbetaAlzheimer’sdiseaseTauPHF6ProteinmisfoldingaggregationInhibitorinhibitorinhibit

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Cl-NQTrp
Cat. No.:
HY-138643
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