Tau Peptide (275-305) (Repeat 2 domain)

Name: Tau Peptide (275-305) (Repeat 2 domain)
Brand: MedChemExpress
SKU: HY-P2516
Rating: 4.5 (0 reviews)

Cat. No.: HY-P2516 Purity: 98.83%: Data Sheet
COA

SDS
Handling Instructions
FAQs
Technical Support

Tau Peptide (275-305) (Repeat 2 domain) is the Alzheimer's Tau fragment R2, corresponding to the second repeat unit of the microtubule-binding domain, which is believed to be pivotal to the biochemical properties of full tau protein. Tau Peptide (275-305) specifically coordinates with group IIB metal ions (Zn²⁺, Cd²⁺, Hg²⁺), which can induce their conformational changes and significantly promote their pathological accumulation. Tau Peptide (275-305) can be used to study the role of heavy metals in neurodegenerative diseases.

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Custom Peptide Synthesis

Tau Peptide (275-305) (Repeat 2 domain) 화학구조

CAS No. : 330456-25-2

사이즈	재고	수량
1 mg	해외재고보유	Estimated Time of Arrival: December 31
5 mg	해외재고보유	Estimated Time of Arrival: December 31
10 mg	해외재고보유	Estimated Time of Arrival: December 31
50 mg	견적 받기
100 mg	견적 받기

or 대량구매 문의

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

This product is a controlled substance and not for sale in your territory.

고객리뷰

Based on 1 Customer Validation

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•Related Small Molecules:

•Related Proteins:

Biological Activity
순도&문서
References
고객리뷰

제품 설명

분자량

3264.71

화학식

C₁₃₉H₂₃₉N₄₃O₄₅S

CAS No.

330456-25-2

Appearance

Solid

Color

White to off-white

Sequence

Val-Gln-Ile-Ile-Asn-Lys-Lys-Leu-Asp-Leu-Ser-Asn-Val-Gln-Ser-Lys-Cys-Gly-Ser-Lys-Asp-Asn-Ile-Lys-His-Val-Pro-Gly-Gly-Gly-Ser

Sequence Shortening

VQIINKKLDLSNVQSKCGSKDNIKHVPGGGS

선적

Room temperature in continental US; may vary elsewhere.

보관

Sealed storage, away from moisture

Powder	-80°C	2 years
	-20°C	1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

용액&용해도

In Vitro:

H₂O : ≥ 25 mg/mL (7.66 mM)

DMSO : 12.5 mg/mL (3.83 mM; adjust pH to 3 with 1 M HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	0.3063 mL	1.5315 mL	3.0631 mL
5 mM	0.0613 mL	0.3063 mL	0.6126 mL
10 mM	---	---	---

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

몰농도 계산기
농도 희석 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

순도&문서

Purity: 98.83%

Select Batch:

Data Sheet (269 KB) SDS (252 KB)

COA (243 KB) LCMS (99 KB) Elemental Analysis Report (101 KB)

Handling Instructions (2659 KB)

References

[1]. Dan-Jing Yang, et al. Mercury(II) promotes the in vitro aggregation of tau fragment corresponding to the second repeat of microtubule-binding domain: Coordination and conformational transition. Biopolymers. 2010 Dec;93(12):1100-7. [Content Brief]

[2]. Yang DJ, et al. Cooperative folding of tau peptide by coordination of group IIB metal cations during heparin-induced aggregation. Biometals. 2012 Apr;25(2):361-72.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	0.3063 mL	1.5315 mL	3.0631 mL	7.6576 mL
H₂O	5 mM	0.0613 mL	0.3063 mL	0.6126 mL	1.5315 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.