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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
10 Results for "
PRAK
" in MedChemExpress (MCE) Product Catalog:
Products (10)
10 Results for "PRAK" in MCE Product Catalog:
2
2 Cited Publications
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Research Areas:
PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
Cat. No.: HY-184792
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CA/PRAK-IN-1 is a dual inhibitor of carbonic anhydrase (Carbonic Anhydrase) and PRAK, with a Ki of 20.1 nM against hCA IX and 16.4 nM against hCA XII. CA/PRAK-IN-1 exhibits inhibitory activity against YES1 kinase, BTK, and MAP4K3. CA/PRAK-IN-1 induces G0/G1 phase arrest of the cancer cell cycle, inhibits DNA synthesis, disrupts hypoxia-driven survival pathways, promotes cell death, and shows broad-spectrum cytotoxicity against tumor cells. CA/PRAK-IN-1 can be used in research on various cancers including leukemia, colon cancer, melanoma, and renal cancer .
Cat. No.: HY-RS08135
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MAPKAPK5 Human Pre-designed siRNA Set A contains three designed siRNAs for MAPKAPK5 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P74621
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK5; MAPKAP Kinase 5; MAPK Activated Protein Kinase 5; MAPKAP-K5; PRAK; MAPKAPK-5; MK5; MK-5; Mitogen-Activated Protein Kinase-Activated Protein Kinase 5; Non-Specific Serine/Threonine Protein Kinase; P38-Regulated/Activated Protein Kinase; MAPK-Acti
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Cat. No.: HY-107427R
CAS No.: 1276121-88-0
Research Areas:
PF-3644022 (Standard) is the analytical standard of PF-3644022 (HY-107427). This product is intended for research and analytical applications. PF-3644022 is a potent, selective, orally active and ATP-competitive MAPKAPK2 (MK2) inhibitor with an IC50 of 5.2 nM and a Ki of 3 nM. PF-3644022 also inhibits MK3 and p38 regulated/activated Kinase (PRAK) with IC50s of 53 nM and 5.0 nM, respectively. PF-3644022 potently inhibits TNFα production and has anti-inflammatory effect .
Cat. No.: HY-P702664
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: MAPKAPK5; MAPKAP Kinase 5; MAPK Activated Protein Kinase 5; MAPKAP-K5; PRAK; MAPKAPK-5; MK5; MK-5; Mitogen-Activated Protein Kinase-Activated Protein Kinase 5; Non-Specific Serine/Threonine Protein Kinase; P38-Regulated/Activated Protein Kinase; MAPK-Acti
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Cat. No.: HY-P85333A
Synonyms: MAPKAPK5; PRAK; MAP kinase-activated protein kinase 5; MAPK-activated protein kinase 5; MAPKAP kinase 5; MAPKAP-K5; MAPKAPK-5; MK-5; MK5; p38-regulated/activated protein kinase; PRAK
Cat. No.: HY-RS17135
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Mapkapk5 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Mapkapk5 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P703736
Purity: ≥ 90%, as determined by reducing SDS-PAGE.;≥ 95%, as determined by HPLC.
Synonyms: MAPKAPK5; MAPKAP Kinase 5; MAPK Activated Protein Kinase 5; MAPKAP-K5; PRAK; MAPKAPK-5; MK5; MK-5; Mitogen-Activated Protein Kinase-Activated Protein Kinase 5; Non-Specific Serine/Threonine Protein Kinase; P38-Regulated/Activated Protein Kinase; MAPK-Acti
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
