6 Results for "

RO 61

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "RO 61" in MCE Product Catalog:

5
5 Cited Publications
Cat. No.: HY-12347
CAS No.: 199666-03-0
Purity:  99.76%
Target:  

KMO

Research Areas:  

Neurological Disease

Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .
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1
1 Cited Publications
Cat. No.: HY-17352
CAS No.: 180384-56-9
Synonyms: RO 61-1790; VML 588; AXV-034343
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction .
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1
1 Cited Publications
Cat. No.: HY-17352A
CAS No.: 503271-02-1
Synonyms: RO 61-1790 disodium; VML 588 disodium; AXV-034343 disodium
Target:  

Endothelin Receptor

Research Areas:  

Cardiovascular Disease

Clazosentan disodium (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan disodium inhibits ET-1-mediated vasoconstriction. Clazosentan disodium prevents cerebral vasospasm, vasospasm-related cerebral infarction .
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Cat. No.: HY-17352R
CAS No.: 180384-56-9
Synonyms: RO 61-1790 (Standard); VML 588 (Standard); AXV-034343 (Standard)
Clazosentan (Standard) is the analytical standard of Clazosentan. This product is intended for research and analytical applications. Clazosentan (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan inhibits ET-1-mediated vasoconstriction. Clazosentan prevents cerebral vasospasm, vasospasm-related cerebral infarction .
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Cat. No.: HY-12347R
CAS No.: 199666-03-0
Target:  

KMO

Research Areas:  

Neurological Disease

Ro 61-8048 (Standard) is the analytical standard of Ro 61-8048. This product is intended for research and analytical applications. Ro 61-8048 is an orally active and selective inhibitor of kynurenine 3-hydroxylase, with an IC50 of 37 nM. Ro 61-8048 provokes a significant increase of extracellular kynurenic acid concentrations .
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Cat. No.: HY-126194
CAS No.: 204853-33-8
Synonyms: RO 61-1448
Tolcapone 3-β-D-glucuronide (Ro 61-1448) is an O-methyl metabolite of Tolcapone (HY-17406) and is pharmacologically inactive. Tolcapone (Ro 40-7592) is a selective, potent and orally active COMT inhibitor with an IC50of 773 nM. Tolcapone can inhibits α-syn and Aβ42 oligomerization and fibrillogenesis. Tolcapone can cause oxidative stress and induce cancer cells apoptosis and ROS production. Tolcapone can be used for the researches of cancer and neurological disease, such as Parkinson disease and neuroblastoma .
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