503271-02-1
Chemical Structure
Clazosentan disodium
Synonym(s): Ro 61-1790 disodium; VML 588 disodium; AXV-034343 disodium
- CAS No.: 503271-02-1
- Formula:C25H23N9Na2O6S
- Molecular Weight:623.55
IUPAC Name: N-(2-(2-(2H-tetrazol-5-yl)pyridin-4-yl)-6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)pyrimidin-4-yl)-5-methylpyridine-2-sulfonamide, disodium salt
InChIKey: OWNLBXJUYMBZFR-UHFFFAOYSA-N
SMILES: O=S(C1=NC=C(C)C=C1)(NC2=NC(C3=CC(C4=NNN=N4)=NC=C3)=NC(OCCO)=C2OC5=CC=CC=C5OC)=O.[Na].[Na]
Biological Activity: Clazosentan disodium (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan disodium inhibits ET-1-mediated vasoconstriction. Clazosentan disodium prevents cerebral vasospasm, vasospasm-related cerebral infarction[1][5].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Clazosentan disodium | 99.94% | Clazosentan disodium (Ro 61-1790) is a selective endothelin A (ETA) receptor antagonist. Clazosentan disodium inhibits ET-1-mediated vasoconstriction. Clazosentan disodium prevents cerebral vasospasm, vasospasm-related cerebral infarction. | ||||||||||||||||||||
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- [1]. Juif PE, et al. Clinical Pharmacology of Clazosentan, a Selective Endothelin A Receptor Antagonist for the Prevention and Treatment of aSAH-Related Cerebral Vasospasm. Front Pharmacol. 2021 Feb 4;11:628956. [Content Brief]
- [5]. Juif PE, et al. Influence of Rifampin-Mediated Organic Anion-Transporting Polypeptide 1B1/1B3 Inhibition on the Pharmacokinetics of Clazosentan. Clin Transl Sci. 2019 Sep;12(5):440-444. [Content Brief]
Keywords
