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Isoforms Recommended: SGK2
Results for "

SGK2

" in MedChemExpress (MCE) Product Catalog:

11

Inhibitors & Agonists

1

Recombinant Proteins

4

Oligonucleotides

Targets Recommended:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-15193
    EMD638683
    15+ Cited Publications

    		 SGK NOD-like Receptor (NLR) Interleukin Related Apoptosis Cardiovascular Disease Cancer
    EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer [2] .
    EMD638683
  • HY-15192
    GSK 650394
    25+ Cited Publications

    		 SGK Influenza Virus Infection Cancer
    GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.
    GSK 650394
  • HY-15193B
    EMD638683 (S-Form)

    		SGK Drug Isomer Cardiovascular Disease Cancer
    EMD638683 (S-Form) (Compound 1a), the S-enantiomer of EMD638683 (HY-15193), is a SGK1 inhibitor with an IC50 value > 300 nM. EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer [2] .
    EMD638683 (S-Form)
  • HY-170933
    SGK1-IN-6

    		SGK Cancer
    SGK1-IN-6 is a selective SGK1 inhibitor with an IC50 of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer .
    SGK1-IN-6
  • HY-E70860
    SGK2 Recombinant Human Active Protein Kinase

    		SGK Cancer
    SGK2 belongs to the SGK family of AGC kinases, which includes SGK1, SGK2, and SGK3 gene. SGK2 upregulation promotes the progression of metastasis in bladder, kidney, and colon cancers. SGK2 Recombinant Human Active Protein Kinase is a recombinant SGK2 protein that can be used to study SGK2-related functions .
    SGK2 Recombinant Human Active Protein Kinase
  • HY-RS12801
    SGK2 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SGK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SGK2 Human Pre-designed siRNA Set A
    SGK2 Human Pre-designed siRNA Set A
  • HY-15192R
    GSK 650394 (Standard)

    		SGK Influenza Virus Infection Cancer
    GSK 650394 (Standard) is the analytical standard of GSK 650394. This product is intended for research and analytical applications. GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.
    GSK 650394 (Standard)
  • HY-RS20819
    Sgk2 Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sgk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sgk2 Mouse Pre-designed siRNA Set A
    Sgk2 Mouse Pre-designed siRNA Set A
  • HY-RS27333
    Sgk2 Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Sgk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sgk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Sgk2 Rat Pre-designed siRNA Set A
    Sgk2 Rat Pre-designed siRNA Set A
  • HY-15193R
    EMD638683 (Standard)

    		Reference Standards SGK NOD-like Receptor (NLR) Interleukin Related Apoptosis Cardiovascular Disease Cancer
    EMD638683 (Standard) is the analytical standard of EMD638683. This product is intended for research and analytical applications. EMD638683 is an orally effective SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer.
    EMD638683 (Standard)
  • HY-RS12802
    SGK3 Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    SGK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    SGK3 Human Pre-designed siRNA Set A
    SGK3 Human Pre-designed siRNA Set A

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