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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
14 Results for "
SGK2
" in MedChemExpress (MCE) Product Catalog:
Products (14)
14 Results for "SGK2" in MCE Product Catalog:
27
27 Cited Publications
Target:
GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.
18
18 Cited Publications
Research Areas:
EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer [2] .
Target:
Research Areas:
EMD638683 (S-Form) (Compound 1a), the S-enantiomer of EMD638683 (HY-15193), is a SGK1 inhibitor with an IC50 value > 300 nM. EMD638683 is an orally active SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer [2] .
Cat. No.: HY-170933
CAS No.: 3046378-98-4
SGK1-IN-6 is a selective SGK1 inhibitor with an IC50 of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer .
Cat. No.: HY-E70860
SGK2 belongs to the SGK family of AGC kinases, which includes SGK1, SGK2, and SGK3 gene. SGK2 upregulation promotes the progression of metastasis in bladder, kidney, and colon cancers. SGK2 Recombinant Human Active Protein Kinase is a recombinant SGK2 protein that can be used to study SGK2-related functions .
Cat. No.: HY-RS12801
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Research Areas:
SGK2 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15192R
CAS No.: 890842-28-1
Target:
GSK 650394 (Standard) is the analytical standard of GSK 650394. This product is intended for research and analytical applications. GSK 650394 is a novel SGK inhibitor with IC50 of 62 nM and 103 nM for SGK1 and SGK2 in the SPA assay respectively. GSK 650394 also inhibits influenza virus replication.
Cat. No.: HY-RS20819
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Research Areas:
Sgk2 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sgk2 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS27333
Target:
Research Areas:
Sgk2 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sgk2 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-15193R
CAS No.: 1181770-72-8
Research Areas:
EMD638683 (Standard) is the analytical standard of EMD638683. This product is intended for research and analytical applications. EMD638683 is an orally effective SGK1 inhibitor with an IC50 of 3 μM. EMD638683 exhibits strong inhibition against SGK1, moderate inhibition against SGK2 and SGK3, and shows excellent selectivity for other AGC kinase family members. EMD638683 has antihypertensive activity by inhibiting SGK1, and independently of the blood pressure-lowering effect, it effectively prevents heart inflammation and fibrosis caused by hypertension by inhibiting the cardiac NLRP3 inflammation body/ IL-1β axis. EMD638683 promotes apoptosis of colon cancer cells and sensitizes radiotherapy. EMD638683 (S-Form) can be used in research related to hypertension, hypertensive heart damage, and colon cancer.
Cat. No.: HY-P705599
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SGK2; Non-Specific Serine/Threonine Protein Kinase; Serum/Glucocorticoid Regulated Kinase 2; Serum/Glucocorticoid-Regulated Kinase 2; Serine/Threonine-Protein Kinase SGK2; DJ138B7.2; SGK2, Serine/Threonine Kinase 2; H-SGK2
Species:
Source:
Cat. No.: HY-P706101
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: SGK2; Non-Specific Serine/Threonine Protein Kinase; Serum/Glucocorticoid Regulated Kinase 2; Serum/Glucocorticoid-Regulated Kinase 2; Serine/Threonine-Protein Kinase SGK2; DJ138B7.2; SGK2, Serine/Threonine Kinase 2; H-SGK2
Species:
Source:
Cat. No.: HY-RS12802
Target:
Research Areas:
SGK3 Human Pre-designed siRNA Set A contains three designed siRNAs for SGK3 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P76063
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: SGK3; CISK; Prev. SGKL; Serum/Glucocorticoid Regulated Kinase-Like; Prev. SGK2; Serum/Glucocorticoid-Regulated Kinase-Like; Serine/Threonine-Protein Kinase SGK3; Serum/Glucocorticoid-Regulated Kinase 3; Cytokine-Independent Survival Kinase; Serum/Glucocor
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
