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Art. -Nr.: HY-170933

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SGK1-IN-6

SGK1-IN-6 is a selective SGK1 inhibitor with an IC₅₀ of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 3046378-98-4
Formel: C₃₀H₃₀F₃N₅O₄
Molecular Weight:581.59

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

SGK1-IN-6 Chemical Structure

CAS. Nr.: 3046378-98-4

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Preis

Verfügbarkeit

Menge

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

SGK1

0.39 μM (IC₅₀)

SGK2

1.76 μM (IC₅₀)

SGK3

1.95 μM (IC₅₀)

Alle SGK Isoform-spezifische Produkte anzeigen :

In Vitro

SGK1-IN-6 (compound 12f) (0.1-1 μM; 24-48 h) inhibits cell migration in PC3 cells in a dose dependent manner^[1].
SGK1-IN-6 (0.1-1 μM; 24-48 h) inhibits cell invasion in PC3 cells in a dose dependent manner^[1].
SGK1-IN-6 (0.01-10 μM; 2 h) can target SGK1 protein enrichment in living cells by
enhancing the thermal stability of the target protein SGK1^[1].
SGK1-IN-6 (0.05-2 μM; 0-48 h) inhibits SGK1 and its substrate phosphorylation in time- and concentration-dependent manner in PC3 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

PC3 cells
Concentration:

0.1; 0.5; 1 μM
Incubation Time:

24; 48 h
Result:

Showed varying degrees of reduction compared to the DMSO group at 0.5 μM and 1 μM, by 24 h.
Significantly decreasedcell migration rates in all groups, by 48 h.

Cell Invasion Assay^[1]

Cell Line:

PC3 cells
Concentration:

0.1; 0.5; 1 μM
Incubation Time:

24 h
Result:

Demonstrate significant concentration-dependent inhibition of PC3 cell invasion.

Western Blot Analysis^[1]

Cell Line:

PC3 cells
Concentration:

0.05; 0.1; 0.5; 1; 2 μM
Incubation Time:

0; 6; 12; 24; 32; 48 h
Result:

Revealed a time-dependent inhibition of NEDD4-2, MDM2, GSK3β, NDRG1, and
SGK1 phosphorylation in PC3 cells.
Showed a time-dependent inhibition of NEDD4-2, MDM2, GSK3β, NDRG1, and
SGK1 phosphorylation in PC3 cells.
Suppressed SGK1 protein and phosphorylation in PC3 cells.

In Vivo

SGK1-IN-6 (compound 12f) (0.2-2 mg/kg; i.p.; daily; 14 days) inhibits tumor grwoth in PC3 mouse xenograft models^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nude
mice (4-6 weeks) subcutaneously inoculated PC3 cells^[1]
Dosage:

0.5; 2 mg/kg
Administration:

i.p.; daily; 14 days
Result:

Inhibited tumor grwoth at 0.5 and 2 mg/kg doses.
Exerted minimal in vivo toxicity and did not affect organ morphology in mice.
Showed no body weight changes in each experimental group of mice.

Chemical Information

CAS. Nr. 3046378-98-4
Molecular Weight 581.59
Formel C₃₀H₃₀F₃N₅O₄
SMILES

O=C(C1=CC2=C(C(F)(F)F)C=C(NC3=CC=C(N4CCNCC4)C=C3OC)N=C2C=C1OC)NC5=CC=C(C=C5)OC
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Li C, et al. Hit to lead optimization of the 4-trifluoromethylquinoline derivatives as novel SGK1 inhibitors with potent anti-prostate cancer activity. Eur J Med Chem. 2025;287:117336. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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Art. -Nr.:
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SGK1-IN-6

Alle SGK Isoform-spezifische Produkte anzeigen