2. Metabolic Enzyme/Protease
  3. SGK
  4. SGK1-IN-6

SGK1-IN-6 is a selective SGK1 inhibitor with an IC50 of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer.

For research use only. We do not sell to patients.

SGK1-IN-6

SGK1-IN-6 Chemical Structure

CAS No. : 3046378-98-4

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SGK1-IN-6 Related Antibodies

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Description

SGK1-IN-6 is a selective SGK1 inhibitor with an IC50 of 0.39 μM, showing selectivity over SGK2/3. SGK1-IN-6 inhibits cancer cell migration and invasion, improves SGK1 protein thermal stability. SGK1-IN-6 decreases SGK1 protein levels in tumor tissues, suppresses tumor growth in mouse xenograft models. SGK1-IN-6 can be used for the research of prostate cancer[1].

IC50 & Target[1]

SGK1

0.39 μM (IC50)

SGK2

1.76 μM (IC50)

SGK3

1.95 μM (IC50)

In Vitro

SGK1-IN-6 (compound 12f) (0.1-1 μM; 24-48 h) inhibits cell migration in PC3 cells in a dose dependent manner[1].
SGK1-IN-6 (0.1-1 μM; 24-48 h) inhibits cell invasion in PC3 cells in a dose dependent manner[1].
SGK1-IN-6 (0.01-10 μM; 2 h) can target SGK1 protein enrichment in living cells by
enhancing the thermal stability of the target protein SGK1[1].
SGK1-IN-6 (0.05-2 μM; 0-48 h) inhibits SGK1 and its substrate phosphorylation in time- and concentration-dependent manner in PC3 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGK1-IN-6 Related Antibodies

Cell Migration Assay [1]

Cell Line: PC3 cells
Concentration: 0.1; 0.5; 1 μM
Incubation Time: 24; 48 h
Result: Showed varying degrees of reduction compared to the DMSO group at 0.5 μM and 1 μM, by 24 h.
Significantly decreasedcell migration rates in all groups, by 48 h.

Cell Invasion Assay[1]

Cell Line: PC3 cells
Concentration: 0.1; 0.5; 1 μM
Incubation Time: 24 h
Result: Demonstrate significant concentration-dependent inhibition of PC3 cell invasion.

Western Blot Analysis[1]

Cell Line: PC3 cells
Concentration: 0.05; 0.1; 0.5; 1; 2 μM
Incubation Time: 0; 6; 12; 24; 32; 48 h
Result: Revealed a time-dependent inhibition of NEDD4-2, MDM2, GSK3β, NDRG1, and
SGK1 phosphorylation in PC3 cells.
Showed a time-dependent inhibition of NEDD4-2, MDM2, GSK3β, NDRG1, and
SGK1 phosphorylation in PC3 cells.
Suppressed SGK1 protein and phosphorylation in PC3 cells.
In Vivo

SGK1-IN-6 (compound 12f) (0.2-2 mg/kg; i.p.; daily; 14 days) inhibits tumor grwoth in PC3 mouse xenograft models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude
mice (4-6 weeks) subcutaneously inoculated PC3 cells[1]
Dosage: 0.5; 2 mg/kg
Administration: i.p.; daily; 14 days
Result: Inhibited tumor grwoth at 0.5 and 2 mg/kg doses.
Exerted minimal in vivo toxicity and did not affect organ morphology in mice.
Showed no body weight changes in each experimental group of mice.
Molecular Weight

581.59

Formula

C30H30F3N5O4
CAS No.
SMILES

O=C(C1=CC2=C(C(F)(F)F)C=C(NC3=CC=C(N4CCNCC4)C=C3OC)N=C2C=C1OC)NC5=CC=C(C=C5)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGK1-IN-6 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGK1-IN-63046378-98-4SGKSerum-glucocorticoid regulated kinaseSerum and glucocorticoid-regulated kinaseSGK1Glu183cancer cell migrationtumor tissuesxenograft modelsSGK3prostate cancerSGK2cancer cell invasionInhibitorinhibitorinhibit

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