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Results for "

SMN2

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (1) Bacterial (1) Dihydrofolate reductase (DHFR) (2) DNA/RNA Synthesis (20) Fungal (1) Isotope-Labeled Compounds (2) Parasite (1) Potassium Channel (2) Reference Standards (2) Small Interfering RNA (siRNA) (2)
By Research Areas:	Cancer (2) Infection (1) Inflammation/Immunology (1) Neurological Disease (13)
Oligonucleotides:	Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) Antisense Oligonucleotides (4) siRNAs (2)

Inhibitors & Agonists

Isotope-Labeled Compounds

Antibodies

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-109101

Risdiplam 5+ Cited Publications RG7916; RO7034067	DNA/RNA Synthesis	Neurological Disease
Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed *SMN2* pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-112980

Nusinersen 5 Publications Verification	DNA/RNA Synthesis	Neurological Disease
Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length *SMN* protein. Nusinersen improves spinal muscular atrophy ^[2] .

HY-19620

Branaplam Maximum Cited Publications 16 Publications Verification LMI070; NVS-SM1	DNA/RNA Synthesis Potassium Channel	Cancer
Branaplam (LMI070; NVS-SM1) is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model ^[2].

HY-112980A

Nusinersen sodium 5 Publications Verification	DNA/RNA Synthesis	Neurological Disease
Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length *SMN* protein. Nusinersen sodium improves spinal muscular atrophy ^[2] .

HY-19620A

Branaplam hydrochloride Maximum Cited Publications 16 Publications Verification LMI070 hydrochloride; NVS-SM1 hydrochloride	DNA/RNA Synthesis Potassium Channel	Cancer
Branaplam (LMI070; NVS-SM1) hydrochloride is a highly potent, selective and orally active survival motor neuron-2 (SMN2) splicing modulator with an EC₅₀ of 20 nM for SMN. Branaplam hydrochloride inhibits human-ether-a-go-go-related gene (hERG) with an IC₅₀ of 6.3 μM. Branaplam hydrochloride elevates full-length SMN protein and extends survival in a severe spinal muscular atrophy (SMA) mouse model ^[2].

HY-101792

RG7800 5 Publications Verification RO6885247	DNA/RNA Synthesis	Others
RG7800 is a *SMN2* splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

HY-117389

Homocarbonyltopsentin PK4C9	DNA/RNA Synthesis	Others
Homocarbonyltopsentin (PK4C9) is a small-molecule *TSL2*-binding compound, binds to pentaloop conformations of TSL2 and promotes a shift to triloop conformations that display enhanced SMN2 exon 7 (E7) splicing with EC₅₀ value of 16 μM .

HY-112633

SMN-C3	DNA/RNA Synthesis	Others
SMN-C3 is an orally active *SMN2* splicing modulator and has the potential to treat spinal muscular atrophy (SMA).

HY-124648

SMN-C2	DNA/RNA Synthesis	Inflammation/Immunology
SMN-C2, an analog of RG-7916, is a selective modulator of *SMN2* gene splicing that acts by binding SMN2 pre-mRNA, thereby increasing far upstream element binding protein 1 (FUBP1) and KH-spliced RNA binding Protein affinity regulator protein (KHSRP) to the SMN2 pre-mRNA complex. SMN-C2 can be used in spinal muscular atrophy (SMA) research .

HY-101792A

RG7800 tetrahydrochloride 5 Publications Verification RO6885247 tetrahydrochloride	DNA/RNA Synthesis	Neurological Disease
RG7800 hydrochloride is an orally active SMN2 splicing modulator, with EC_1.5xs of 23 nM and 87 nM for SMN2 splicing and SMN protein; RG7800 hydrochloride has the potential to treat spinal muscular atrophy.

HY-111520

NVS-SM2	DNA/RNA Synthesis	Neurological Disease
NVS-SM2 is a potent, orally active and brain-penetrant SMN2 splicing enhancer with an EC₅₀ of 2 nM for SMN. NVS-SM2 enhances U1-pre-mRNA association. NVS-SM2 promotes exon 7 inclusion and restores normal survival motor neuron (SMN) protein expression. NVS-SM2 can be used for spinal muscular atrophy (SMA) research ^[2].

HY-109101S

Risdiplam-d4 1 Publications Verification	DNA/RNA Synthesis	Neurological Disease
Risdiplam-d₄ is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-121473

Aklavin	Antibiotic Bacterial Fungal Parasite	Infection
Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene ^[2] .

HY-RS13439

SMN2 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SMN2 Human Pre-designed siRNA Set A contains three designed siRNAs for SMN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SMN2 Human Pre-designed siRNA Set A SMN2 Human Pre-designed siRNA Set A

HY-124640

SMN2 modulator-1	DNA/RNA Synthesis	Neurological Disease
SMN2 modulator-1 is a brain-penetrant survival motor neuron (SMN) modulator. SMN2 modulator-1 post-translationally stabilizes SMN protein and increases SMN protein levels independent of SMN2 transcription. SMN2 modulator-1 can be used for the research of spinal muscular atrophy^[1].

HY-117000A

D156844 hydrochloride	DNA/RNA Synthesis Dihydrofolate reductase (DHFR)	Neurological Disease
D156844 (Compound 11a) hydrochloride is a SMN2 promoter activator with an EC₅₀ of 4 nM. D156844 hydrochloride increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 hydrochloride overcomes DHFR inhibition. D156844 hydrochloride can be used for SMA research .

HY-109101R

Risdiplam (Standard) RG7916 (Standard); RO7034067 (Standard)	Reference Standards DNA/RNA Synthesis	Neurological Disease
Risdiplam (Standard) is the analytical standard of Risdiplam. This product is intended for research and analytical applications. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed *SMN2* pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-117000

D156844	DNA/RNA Synthesis Dihydrofolate reductase (DHFR)	Neurological Disease
D156844 (Compound 11a) is a SMN2 promoter activator with an EC₅₀ of 4 nM. D156844 increases the mRNA expression of the mouse SMN in NSC-34 cells and human SMN2 promoter in severe type I spinal muscular atrophy (SMA) fibroblasts as well as full-length human SMN protein. D156844 overcomes DHFR inhibition. D156844 can be used for SMA research .

HY-109101AS1

Risdiplam-hydroxylate-d3	Isotope-Labeled Compounds DNA/RNA Synthesis	Neurological Disease
Risdiplam-hydroxylate-d₃ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-109101AS2

Risdiplam-hydroxylate-d6	Isotope-Labeled Compounds DNA/RNA Synthesis	Neurological Disease
Risdiplam-hydroxylate-d₆ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-101792R

RG7800 (Standard) RO6885247 (Standard)	Reference Standards DNA/RNA Synthesis	Others
RG7800 (Standard) (RO6885247 (Standard)) is the analytical standard of RG7800 (HY-101792). This product is intended for research and analytical applications. RG7800 is a SMN2 splicing modifier. RG7800 has the potential for spinal muscular atrophy treatment.

HY-RS05838

Grm7 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Grm7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Grm7 Mouse Pre-designed siRNA Set A Grm7 Mouse Pre-designed siRNA Set A

HY-102020A

RG3039 hydrochloride	DNA/RNA Synthesis	Neurological Disease
RG3039 hydrochloride is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC₅₀ of 4.2 nM against hDcpS. RG3039 hydrochloride inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 hydrochloride extends survival and improves function in spinal muscular atrophy mice. RG3039 hydrochloride is applicable to research related to spinal muscular atrophy ^[2].

Cat. No.	Product Name	Chemical Structure

HY-109101S

Risdiplam-d4 1 Publications Verification
Risdiplam-d₄ is deuterium labeled Risdiplam. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-109101AS1

Risdiplam-hydroxylate-d3
Risdiplam-hydroxylate-d₃ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

HY-109101AS2

Risdiplam-hydroxylate-d6
Risdiplam-hydroxylate-d₆ is a Risdiplam-hydroxylate tritium substitute. Risdiplam (RG7916) is an orally administered, centrally and peripherally distributed SMN2 pre-mRNA splicing modifier that increases survival motor neuron (SMN) protein levels .

Host:	Mouse (4) Rabbit (2)
Reactivity:	Human (6) Rat (2) Mouse (2) Monkey (4)
Application:	IHC-P (6) ICC/IF (2) IF-Tissue (1) IP (2) IHC-F (1) WB (6) FC (2) ELISA (4)
Isotype:	IgG (2) IgG1 (4)
Conjugation:	Non-conjugated (6)
Clonality:	Monoclonal (3) Monoclonal Antibody (1) Recombinant (2)
Modification:	Unmodified (4)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P85371

	SMN1 Antibody (YA5063) SMN1; SMN; SMNT; SMN2; SMNC; Survival motor neuron protein; Component of gems 1; Gemin-1	WB, IHC-P, IHC-F, IP, IF-Tissue	Human, Mouse, Rat
	SMN1 Antibody (YA5063) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to SMN1.

HY-P84617

	SMN1 Antibody (YA4314) SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMN2; SMNT; BCD541; T-BCD541	WB, IHC-P, FC, ELISA	Human, Monkey
	SMN1 Antibody (YA4314) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMN1.

HY-P84618

	SMN1 Antibody (YA4315) SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMN2; SMNT; BCD541; T-BCD541	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
	SMN1 Antibody (YA4315) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMN1.

HY-P84617A

	SMN1 Antibody (YA4314)(PBS only) SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMN2; SMNT; BCD541; T-BCD541	WB, IHC-P, FC, ELISA	Human, Monkey
	SMN1 Antibody (YA4314) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMN1.

HY-P84618A

	SMN1 Antibody (YA4315)(PBS only) SMA; SMN; SMA1; SMA2; SMA3; SMA4; SMA@; SMN2; SMNT; BCD541; T-BCD541	WB, IHC-P, ICC/IF, ELISA	Human, Monkey
	SMN1 Antibody (YA4315) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to SMN1.

HY-P82449

	SMN1 Antibody (YA2194) SMN1; SMN; SMNT; SMN2; SMNC; Survival motor neuron protein; Component of gems 1; Gemin-1	WB, IHC-P, IP	Human, Mouse, Rat
	SMN1 Antibody (YA2194) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to SMN1.

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Cat. No.	Product Name		Classification

HY-112980

Nusinersen 5 Publications Verification		Antisense Oligonucleotides
Nusinersen is an antisense oligonucleotide active molecule. Nusinersen modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length *SMN* protein. Nusinersen improves spinal muscular atrophy ^[2] .

HY-112980A

Nusinersen sodium 5 Publications Verification		Antisense Oligonucleotides
Nusinersen sodium is an antisense oligonucleotide active molecule. Nusinersen sodium modifies the pre-messenger RNA splicing of the SMN2 gene, thereby promoting the production of full-length *SMN* protein. Nusinersen sodium improves spinal muscular atrophy ^[2] .

HY-RS13439

SMN2 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
SMN2 Human Pre-designed siRNA Set A contains three designed siRNAs for SMN2 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-177661

Salanersen BIIB115; ION306		Antisense Oligonucleotides
Salanersen is an antisense oligonucleotide targeted to survival motor neuron 2 (SMN2). It is used for the study of spinal muscular atrophy (SMA).

HY-177661A

Salanersen sodium BIIB115 sodium; ION306 sodium		Antisense Oligonucleotides
Salanersen sodium is an antisense oligonucleotide targeted to survival motor neuron 2 (SMN2). It is used for the study of spinal muscular atrophy (SMA).

HY-RS05838

Grm7 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Grm7 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Grm7 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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