60504-57-6
Chemical Structure
Aklavin
- CAS No.: 60504-57-6
- Formula:C30H35NO10
- Molecular Weight:569.60
IUPAC Name: methyl (1R,2R,4S)-4-(((2R,4S,5S,6S)-4-(dimethylamino)-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-2,5,7-trihydroxy-6,11-dioxo-1,2,3,4,6,11-hexahydrotetracene-1-carboxylate
InChIKey: LJZPVWKMAYDYAS-QKKPTTNWSA-N
SMILES: COC([C@@H]1C2=C(C(O)=C3C(C(C4=CC=CC(O)=C4C3=O)=O)=C2)[C@H](C[C@]1(O)CC)O[C@H]5C[C@@H]([C@@H]([C@@H](O5)C)O)N(C)C)=O
Biological Activity: Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene[1][2][3].
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Aklavin | Aklavin is a structural analog of Aclacinomycin A (HY-N2306) produced by Streptomyces strain A 1165. Aklavin possesses Z-DNA-inducing and stabilizing activities, along with antibiotic, anti-phage and broad-spectrum antimicrobial activities. Aklavin inhibits the proliferation of various viruses (such as influenza virus and poliovirus) and interferes with their nucleoprotein synthesis, while also exhibiting inhibitory effects on staphylococci, mycobacteria and specific fungi. Aklavin blocks phage-induced bacterial lysis by regulating host-parasite interactions. Aklavin shows specific toxicity to fertilized eggs and mice, and does not alter the splicing of the SMN2 gene. | |||||||||||||||||||||
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- [1]. Hur J H, et al. Identification of a new z‐dna inducer using SYBR Green 1 as a DNA conformation sensor[J]. FEBS letters, 2019, 593(18): 2628-2636.
- [2]. Strelitz F, Fet al. Aklavin, an antibiotic substance with antiphage activity[J]. Journal of Bacteriology, 1956, 72(1): 90-94.
- [3]. Andreassi C, et al. Aclarubicin treatment restores SMN levels to cells derived from type I spinal muscular atrophy patients. Hum Mol Genet. 2001;10(24):2841-2849. [Content Brief]
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