10 Results for "

STEAP1

" in MedChemExpress (MCE) Product Catalog:
Products (10)

10 Results for "STEAP1" in MCE Product Catalog:

Cat. No.: HY-P990688
CAS No.: 2559056-68-5
Synonyms: AMG-509

Target:  

CD3

Research Areas:  

Cancer

Xaluritamig (AMG-509) is a bispecific T cell engager and cytolytic agent with a Kd of 27.6 nM for human CD3ε. Xaluritamig binds to CD3ε via an anti-CD3 single-chain variable fragment (scFv) domain, and to STEAP1 via a bispecific anti-STEAP1 antigen-binding fragment (Fab) domain, thereby recruiting and activating T cells and forming a bridge between T cells and STEAP1-expressing cancer cells. Xaluritamig induces T cell-mediated redirected cytotoxicity, tumor cell lysis, cytokine release, CD8 + T cell activation and expansion, as well as tumor stasis or regression. Xaluritamig contains an Fc domain with no effector function, which prolongs serum half-life, exhibits only minimal activity against cells with low STEAP1 expression and normal cells, and shows extremely low target-related off-tumor toxicity in cynomolgus monkeys. Xaluritamig is used in STEAP1×CD3 XmAb 2+1 immunotherapy and in research on metastatic castration-resistant prostate cancer and Ewing sarcoma [1] .
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Cat. No.: HY-P990673
Synonyms: DSTP-3086S Antibody; RG-7450 Antibody

Research Areas:  

Cancer

Vandortuzumab (DSTP-3086S Antibody; RG-7450 Antibody) is a humanized anti-STEAP1 IgG1 antibody and antimitotic agent that can be conjugated with MMAE (HY-15162) to form the antibody-drug conjugate (ADC) Vandortuzumab vedotin. Vandortuzumab vedotin specifically binds to STEAP1 and drives internalization of the complex, releasing the MMAE (HY-15162) payload intracellularly. After binding to tubulin, MMAE inhibits cell division and induces cell death. Vandortuzumab exhibits antitumor activity in preclinical xenograft models of prostate cancer and can be used for research related to metastatic castration-resistant prostate cancer (mCRPC) [1] .
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Cat. No.: HY-138632
CAS No.: 2417370-42-2
Purity:  98.23%
PROTAC BRD4 Degrader linker conjugate is a linker-payload conjugate as well as a bifunctional degrader of BRD4 that binds to VHL, consisting of PROTAC and a linker. PROTAC BRD4 Degrader linker conjugate can be conjugated with STEAP1 and CLL1 antibodies to degrade BRD4 protein, with DC50 values of 0.86 nM and 7.6 nM, respectively. PROTAC BRD4 Degrader linker conjugate can be used in research related to prostate cancer and acute myeloid leukemia (BRD4 ligand: (HY-129939); VHL ligand: (HY-125845)) [1].\n




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Cat. No.: HY-RS13905
Research Areas:  

Others

STEAP1 Human Pre-designed siRNA Set A contains three designed siRNAs for STEAP1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS16998
Research Areas:  

Others

Steap1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Steap1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-RS23441
Research Areas:  

Others

Steap1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Steap1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P99528
CAS No.: 1471985-92-8
Synonyms: DSTP 3086S; RG 7450; MSTP2109A

Research Areas:  

Cancer

Vandortuzumab vedotin (DSTP 3086S; RG 7450) is a STEAP1-targeted antibody-drug conjugate (ADC). Vandortuzumab vedotin binds specifically to STEAP1, triggers internalization of the conjugate complex, mediates intracellular release of monomethyl auristatin E, inhibits cell division, and induces cell death. Vandortuzumab vedotin exhibits antitumor activity in preclinical prostate cancer xenografts. Vandortuzumab vedotin can be used for the research of metastatic castration-resistant prostate cancer [1].
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Cat. No.: HY-RS13906
Research Areas:  

Others

STEAP1B Human Pre-designed siRNA Set A contains three designed siRNAs for STEAP1B gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

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Cat. No.: HY-P702448
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: Metalloreductase STEAP1; Six-transmembrane epithelial antigen of prostate 1
Species:  
Source:  
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Cat. No.: HY-P702449
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: STEAP family member 1
Species:  
Rat
Source:  
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