2 Results for "

SVZ-derived NSCs

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "SVZ-derived NSCs" in MCE Product Catalog:

2
2'-Acetylacteoside
2'-Acetylacteoside
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2 Cited Publications
Cat. No.: HY-N0026
CAS No.: 94492-24-7
Synonyms: 2'-AA
Category:  

Simple Phenylpropanols Other Diseases Scrophulariaceae Phenylpropanoids Plants Disease Research Fields Brandisia hancei Hook. f.

Target:  

Monoamine Oxidase RANKL/RANK TNF Receptor NF-κB IKK

2'-Acetylacteoside (2'-AA) is a natural compound with oral activity and blood-brain barrier permeability. 2'-Acetylacteosideexhibits MAO‑B inhibitory activity (IC50 = 17.71 μM, Ki = 13.81 μM). 2'-Acetylacteoside downregulates the expression of RANK, TRAF6, NF‑κB, NFATc1 and IKKβ, disrupts the RANKL/RANK interaction, blocks downstream signaling pathways, and increases the level of phosphorylated Akt. 2'-Acetylacteoside possesses potent anti-osteoclastogenic, anti-bone resorptive, pro-neurogenic, neuroprotective and antioxidant activities. 2'-Acetylacteoside can be used in the research of osteoporosis, ischemic stroke and Parkinson's disease .
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Clobetasol
Clobetasol
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Cat. No.: HY-W338819
CAS No.: 25122-41-2
Target:  

Smo Hedgehog Gli Glucocorticoid Receptor

Research Areas:  

Neurological Disease Inflammation/Immunology

Clobetasol is a glucocorticoid and Smoothened agonist that can cross the blood-brain barrier. Clobetasol induces Smo-dependent activation of the Shh signaling pathway and nuclear translocation of Gli1. Clobetasol promotes remyelination and reduces myelin loss in lesions of neuromyelitis optica (NMO). Clobetasol may cause adrenal suppression, cushingoid appearance, and local adverse reactions including dysgeusia, xerostomia, and gastroesophageal burning. Clobetasol can be used in research related to neurodegenerative diseases, oral lichen planus, mucous membrane pemphigoid, and neuromyelitis optica .
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