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Sesamin

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By Targets:	Isotope-Labeled Compounds (1) NO Synthase (1) Reference Standards (1) Stearoyl-CoA Desaturase (SCD) (2)
By Research Areas:	Inflammation/Immunology (1) Neurological Disease (3)

Inhibitors & Agonists

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0121

*Sesamin* 10+ Cited Publications	Stearoyl-CoA Desaturase (SCD)	Neurological Disease
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N0121A

(-)-Sesamin	Others	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-N0121R

Sesamin (Standard)	Stearoyl-CoA Desaturase (SCD) Reference Standards	Neurological Disease
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N0121S

Sesamin-d8	Isotope-Labeled Compounds	Neurological Disease
Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N13781

*(-)-Sesamin* 2,2'-diol**	NO Synthase	Inflammation/Immunology
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor with an IC₅₀ of 310 μM for inhibiting LPS-induced NO production. (-)-Sesamin 2,2'-diol can be isolated from the aerial parts of Isodon japonicus. (-)-Sesamin 2,2'-diol abrogates NO production in LPS-stimulated macrophages without inducing cytotoxicity .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N0121

*Sesamin* 10+ Cited Publications	Neurological Disease Classification of Application Fields Anti-aging Sesamum indicum Linn. Lignans Phenylpropanoids Pedaliaceae Plants Disease Research Fields Source Classification	Stearoyl-CoA Desaturase (SCD)
Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N0121A

(-)-Sesamin	Classification of Application Fields Asarum forbesii Maxim. Lignans Other Diseases Phenylpropanoids Plants Disease Research Fields Aristolochiaceae Source Classification	Others
(-)-Sesamin isolated from Asarum forbesii Maxim, is an isomer of Sesamin. Sesamin is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis .

HY-N0121R

Sesamin (Standard)	Structural Classification Sesamum indicum Linn. Lignans Phenylpropanoids Pedaliaceae Plants Source Classification	Stearoyl-CoA Desaturase (SCD) Reference Standards
Sesamin (Standard) is the analytical standard of Sesamin. This product is intended for research and analytical applications. Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

HY-N13781

*(-)-Sesamin* 2,2'-diol**	Acourtia cordata (Cerv.) B.L.Turner Structural Classification Labiatae Lignans Phenylpropanoids Plants Source Classification	NO Synthase
(-)-Sesamin 2,2'-diol is a nitric oxide (NO) production inhibitor with an IC₅₀ of 310 μM for inhibiting LPS-induced NO production. (-)-Sesamin 2,2'-diol can be isolated from the aerial parts of Isodon japonicus. (-)-Sesamin 2,2'-diol abrogates NO production in LPS-stimulated macrophages without inducing cytotoxicity .

Cat. No.	Product Name	Chemical Structure

HY-N0121S

Sesamin-d8
Sesamin-d8 is the deuterium labeled Sesamin (HY-N0121). Sesamin, abundant lignan found in sesame oil, is a potent and selective delta 5 desaturase inhibitor in polyunsaturated fatty acid biosynthesis. Sesamin exerts effective neuroprotection against cerbral ischemia .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Sesamin

Inhibitors & Agonists

NaturalProducts

Isotope-Labeled Compounds

Natural
Products