1 Result for "

SmATPDase 1

" in MedChemExpress (MCE) Product Catalog:
Products (1)

1 Results for "SmATPDase 1" in MCE Product Catalog:

Licoflavone B
Licoflavone B
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Cat. No.: HY-N4184
CAS No.: 91433-17-9
Category:  

Glycyrrhiza inflata Batal. Flavones Plants Infection Flavonoids Leguminosae Phenols Polyphenols Disease Research Fields Glycyrrhiza uralensis Fisch.

Target:  

Parasite Influenza Virus ATP Synthase c-Myc p38 MAPK Apoptosis

Licoflavone B is an orally active flavonoid, with IC50 values of 23.78 μM and 31.5 μM against SmATPase and SmADPase of Schistosoma mansoni, respectively. Licoflavone B selectively targets viral RdRp, inhibits viral replication, and reduces the expression levels of viral NP and PB2. Licoflavone B inhibits c-Myc expression and suppresses cancer cell proliferation. Licoflavone B disrupts the tegument of worms, reduces egg production, and induces the death of adult Schistosoma mansoni. Licoflavone B blocks the activation of the MAPK pathway, maintains colonic barrier integrity, inhibits colonic cell apoptosis, and reshapes the gut microbiota. Licoflavone B can be used in research related to influenza, multiple myeloma, schistosomiasis, and ulcerative colitis [1] .
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