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Results for "

TRHR

" in MedChemExpress (MCE) Product Catalog:

7

Inhibitors & Agonists

1

Isotope-Labeled Compounds

3

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-B0596
    Taltirelin
    1 Publications Verification

    TA-0910

    		 Thyroid Hormone Receptor Apoptosis Neurological Disease Endocrinology
    Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .
    Taltirelin
  • HY-B0596A
    Taltirelin acetate
    1 Publications Verification

    TA-0910 acetate

    		 Thyroid Hormone Receptor Apoptosis Neurological Disease Endocrinology
    Taltirelin acetate (TA-0910) is an acetate form of Taltirelin (TA-0910). Taltirelin (TA-0910) is an orally effective analogue of thyrotropin releasing hormone (TRH) and a TRH receptor (TRH-R) superagonist (IC50 at 910 nM). Taltirelin can cross the blood-brain barrier. Taltirelin stimulates an increase in cytosolic Ca 2+ concentration (Ca 2+ release) with an EC50 value of 36 nM. Taltirelin increases cell viability and reduces apoptosis in SH-SY5Y cells and primary rat mesencephalic neurons treated with MPP+ (HY-W008719) or Rotenone (HY-B1756). Taltirelin has neuroprotective effects in both cellular and animal models of Parkinson's disease. Taltirelin alleviates fatigue-like behavior in mouse models of cancer-related fatigue .
    Taltirelin acetate
  • HY-RS15013
    TRHR Human Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    TRHR Human Pre-designed siRNA Set A contains three designed siRNAs for TRHR gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

    TRHR Human Pre-designed siRNA Set A
    TRHR Human Pre-designed siRNA Set A
  • HY-W331198
    Tralopyril

    		Insecticide Ferroptosis Infection
    Tralopyril is an orally active, blood-brain barrier-penetrating antifouling insecticide and endocrine disruptor. By interfering with the thyroid hormone system and mitochondrial oxidative phosphorylation, Tralopyril downregulates the transcription of genes such as TRHR, Nkx2.1, TRα and induces ferroptosis. Tralopyril disrupts amino acid, energy and lipid metabolism, exhibits significant skeletal and reproductive toxicity, and causes developmental damage. Tralopyril has a long half-life in vivo and wide tissue distribution, posing potential risks to aquatic organisms and human health. Tralopyril shows species specificity in in vitro liver microsomal metabolism, exerts lethal effects on target insects and laboratory animals, and is commonly used in studies of chlorfenapyr poisoning and related toxic mechanisms .
    Tralopyril
  • HY-B0596S
    Taltirelin-13C,d3

    TA-0910-13C,d3

    		 Isotope-Labeled Compounds Thyroid Hormone Receptor Apoptosis Neurological Disease Endocrinology
    Taltirelin- 13C,d3 (TA-0910- 13C,d3) is 13C and deuterated labeled Taltirelin (HY-B0596). Taltirelin (TA0910) is a superagonist at thyrotropin-releasing hormone receptor (TRH-R) with an IC50 of 910 nM and EC50 of 36 nM for stimulating an increase in cytosolic Ca 2+ concentration (Ca 2+ release).
    Taltirelin-13C,d3
  • HY-RS26857
    Trhr Rat Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Trhr Rat Pre-designed siRNA Set A contains three designed siRNAs for Trhr gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Trhr Rat Pre-designed siRNA Set A
    Trhr Rat Pre-designed siRNA Set A
  • HY-RS20348
    Trhr Mouse Pre-designed siRNA Set A

    		Small Interfering RNA (siRNA) Others

    Trhr Mouse Pre-designed siRNA Set A contains three designed siRNAs for Trhr gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

    Trhr Mouse Pre-designed siRNA Set A
    Trhr Mouse Pre-designed siRNA Set A

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