122454-29-9
Chemical Structure
Tralopyril
- CAS No.: 122454-29-9
- Formula:C12H5BrClF3N2
- Molecular Weight:349.53
IUPAC Name: ethyl 1-oxa-2-azaspiro[4.5]dec-2-ene-3-carboxylate
InChIKey: XNFIRYXKTXAHAC-UHFFFAOYSA-N
SMILES: C1=C(C=CC(=C1)Cl)C2=C(C#N)C(=C(C(F)(F)F)N2)Br
Biological Activity: Tralopyril is an orally active, blood-brain barrier-penetrating antifouling insecticide and endocrine disruptor. By interfering with the thyroid hormone system and mitochondrial oxidative phosphorylation, Tralopyril downregulates the transcription of genes such as TRHR, Nkx2.1, TRα and induces ferroptosis. Tralopyril disrupts amino acid, energy and lipid metabolism, exhibits significant skeletal and reproductive toxicity, and causes developmental damage. Tralopyril has a long half-life in vivo and wide tissue distribution, posing potential risks to aquatic organisms and human health. Tralopyril shows species specificity in in vitro liver microsomal metabolism, exerts lethal effects on target insects and laboratory animals, and is commonly used in studies of chlorfenapyr poisoning and related toxic mechanisms[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Tralopyril | 99.70% | Tralopyril is an orally active, blood-brain barrier-penetrating antifouling insecticide and endocrine disruptor. By interfering with the thyroid hormone system and mitochondrial oxidative phosphorylation, Tralopyril downregulates the transcription of genes such as TRHR, Nkx2.1, TRα and induces ferroptosis. Tralopyril disrupts amino acid, energy and lipid metabolism, exhibits significant skeletal and reproductive toxicity, and causes developmental damage. Tralopyril has a long half-life in vivo and wide tissue distribution, posing potential risks to aquatic organisms and human health. Tralopyril shows species specificity in in vitro liver microsomal metabolism, exerts lethal effects on target insects and laboratory animals, and is commonly used in studies of chlorfenapyr poisoning and related toxic mechanisms. | ||||||||||||||||||||
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- [1]. Chen X, et al. Tralopyril induces developmental toxicity in zebrafish embryo (Danio rerio) by disrupting the thyroid system and metabolism. Sci Total Environ. 2020;746:141860. [Content Brief]
- [2]. Liu B, et al. Transgenerational toxicity of Tralopyril: Ferroptosis mediates reproductive and skeletal disruption in Oryzias melastigma[J]. Environmental Chemistry and Ecotoxicology, 2026.
- [3]. Zhang S, et al. Toxicokinetics, in vivo metabolic profiling and tissue distribution of chlorfenapyr in mice. Arch Toxicol. 2024;98(11):3763-3775. [Content Brief]
- [4]. Chung MJ, et al. A Fatal Case of Chlorfenapyr Poisoning and the Therapeutic Implications of Serum Chlorfenapyr and Tralopyril Levels. Medicina (Kaunas). 2022;58(11):1630. Published 2022 Nov 11. [Content Brief]
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