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Tenacissoside A

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Apoptosis (2) NF-κB (1) P-glycoprotein (2) PI3K (1)
By Research Areas:	Cancer (6) Inflammation/Immunology (1) Neurological Disease (1)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N0670

Tenacissoside H 1 Publications Verification Tenacissimoside C	PI3K Akt NF-κB Apoptosis	Neurological Disease Inflammation/Immunology Cancer
Tenacissoside H (Tenacissimoside C) is a compound found in Caulis Marsdeniae Tenacissimae. Tenacissoside H shows anti-inflammation, anti-tumor and neuroprotective effects. Tenacissoside H inhibits PI3K/Akt and NF-κB signaling pathway. Tenacissoside H inhibits cancer cells proliferation, S phase arrest, and inhibits tumor growyh in mice. Tenacissoside H promotes neurological recovery of ischemia-reperfusion injury in mice by inhibiting inflammation and apoptosis. Tenacissoside H can be used for the research of cancer, inflammation and neurological diseases, such as esophageal cancer and cerebral ischemia .

HY-N2103

Tenacissoside G	P-glycoprotein	Cancer
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells .

HY-N13120

Tenacissoside A	Others	Others
Tenacissoside A is an active compound that can be isolated from Marsdenia tenacissima .

HY-N2102

Tenacissoside I	Others	Cancer
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .

HY-N13158

*11α-O-Actety-12β-O-tigloyl Tenacissoside* A**	Others	Cancer
11α-O-Acetyl-12β-O-tigloyl Tenacissoside A is a polyoxypregnane glycoside derived from Marsdenia tenacissima with anti-cancer activity .

HY-N16577

*(S)-Tenacissoside* F**	P-glycoprotein	Cancer
(S)-Tenacissoside F (Compound P20) is a polyoxypregnane compound found in Marsdenia tenacissima. (S)-Tenacissoside F can inhibit the drug efflux activity mediated by P-glycoprotein (P-gp/ABCB1) and reverse multidrug resistance. (S)-Tenacissoside F can be used for the research of cancer, such as colon cancer .

HY-N13125

Tenacissoside E	Others	Others
Tenacissoside E (compound 18) is a polyoxypregnane glycoside .

HY-N13122

Tenacissoside B	Others	Others
Tenacissoside B is an active compound that can be extracted from M. tenacissima.

HY-N13123

Tenacissoside C	Apoptosis	Cancer
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

HY-N1167

Tenacissoside F	Others	Others
Tenacissoside F is a natural product .

Tenacissoside H 1 Publications Verification Tenacissimoside C	Structural Classification other families Classification of Application Fields Plants Disease Research Fields Steroids Source Classification Cancer	PI3K Akt NF-κB Apoptosis
Tenacissoside H (Tenacissimoside C) is a compound found in Caulis Marsdeniae Tenacissimae. Tenacissoside H shows anti-inflammation, anti-tumor and neuroprotective effects. Tenacissoside H inhibits PI3K/Akt and NF-κB signaling pathway. Tenacissoside H inhibits cancer cells proliferation, S phase arrest, and inhibits tumor growyh in mice. Tenacissoside H promotes neurological recovery of ischemia-reperfusion injury in mice by inhibiting inflammation and apoptosis. Tenacissoside H can be used for the research of cancer, inflammation and neurological diseases, such as esophageal cancer and cerebral ischemia .

Tenacissoside G	other families Classification of Application Fields Plants Disease Research Fields Steroids Cancer Source Classification	P-glycoprotein
Tenacissoside G is a C21 steroid from the stems of Marsdenia tenacissima. Tenacissoside G reverses multidrug resistance in P-glycoprotein (Pgp)-overexpressing multidrug-resistant cancer cells .

Tenacissoside A	Structural Classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Steroids Source Classification	Others
Tenacissoside A is an active compound that can be isolated from Marsdenia tenacissima .

Tenacissoside I	other families Classification of Application Fields Plants Disease Research Fields Steroids Cancer Source Classification	Others
Tenacissoside I is a C21 steroid from the Marsdenia tenacissima, which is detected at relatively high level in M. tenacissima .

*11α-O-Actety-12β-O-tigloyl Tenacissoside* A**	Structural Classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Steroids Source Classification	Others
11α-O-Acetyl-12β-O-tigloyl Tenacissoside A is a polyoxypregnane glycoside derived from Marsdenia tenacissima with anti-cancer activity .

*(S)-Tenacissoside* F**	Apocynaceae Structural Classification Plants Steroids Source Classification	P-glycoprotein
(S)-Tenacissoside F (Compound P20) is a polyoxypregnane compound found in Marsdenia tenacissima. (S)-Tenacissoside F can inhibit the drug efflux activity mediated by P-glycoprotein (P-gp/ABCB1) and reverse multidrug resistance. (S)-Tenacissoside F can be used for the research of cancer, such as colon cancer .

Tenacissoside E	Structural Classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Steroids Source Classification	Others
Tenacissoside E (compound 18) is a polyoxypregnane glycoside .

Tenacissoside B	Structural Classification Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Steroids Source Classification	Others
Tenacissoside B is an active compound that can be extracted from M. tenacissima.

Tenacissoside C	Triterpenes Terpenoids Marsdenia tenacissima (Roxb.) Moon Asclepiadaceae Plants Source Classification	Apoptosis
Tenacissoside C is an anti-cancer compound that inhibits angiogenesis. Tenacissoside C induces apoptosis in cancer cells by down-regulating the expression of anti-apoptotic factors and activating caspase-9 and caspase-3. Tenacissoside C also causes cell cycle arrest in cancer cells and induces apoptosis through the mitochondrial pathway.

Tenacissoside F	Apocynaceae Plants Steroids Source Classification	Others
Tenacissoside F is a natural product .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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Tenacissoside A

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