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Tetraasterane

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-W1139353
    Tetraasterane

    		HyT Cancer
    Tetraasterane is a hydrophobic tag that promotes the degradation of ALK protein. Tetraasterane can be used for synthesis of ALK degrader 3 (HY-182087) .
    Tetraasterane
  • HY-182087
    ALK degrader 3

    		HyT Anaplastic lymphoma kinase (ALK) Cancer
    ALK degrader 3 is a ALK HyT degrader with an IC50 of 1.2 nM. ALK degrader 3 inhibits ALK kinase activity, increases the solvent-accessible surface area of hydrophobic residues near the ALK binding pocket, promotes ALK to form a partially unfolded conformation, and drives ALK degradation via the proteasomal pathway. ALK degrader 3 inhibits the proliferation of tumor cells. ALK degrader 3 can be used for the research of non-small cell lung cancer. (ALK ligand: Brigatinib (HY-12857); hydrophobic tag: Tetraasterane (HY-W1139353)) .
    ALK degrader 3

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