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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
U2 snRNP
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "U2 snRNP" in MCE Product Catalog:
Target:
Research Areas:
NSC 194308, a U2AF2-RNA complexes enhancer, increases association of the U2AF1-U2AF2-SF1-splice site RNA complex by binding a site between the U2AF2 RNA recognition motifs (RRM1 and RRM2). NSC 194308 inhibits pre-mRNA splicing by stalling spliceosome assembly at the point where U2AF helps recruit U2 snRNP to the branchpoint. NSC 194308 enhances the binding of pre-mRNA to U2AF2, selectively triggering cell death in leukemia cell lines containing spliceosome mutations .
Cat. No.: HY-133924
CAS No.: 1200128-66-0
Synonyms: RQN-18690A
Target:
Research Areas:
18-Deoxyherboxidiene (RQN-18690A) is a potent angiogenesis inhibitor. 18-Deoxyherboxidiene targets SF3b, a spliceosome component that is a subcomplex of the U2 small nuclear ribonucleoprotein (snRNP) in the spliceosome. 18-Deoxyherboxidiene inhibits the migration and tube formation of human umbilical vein endothelial cells (HUVECs) without significant cell toxicity. 18-Deoxyherboxidiene has the potential for cancer research .
Cat. No.: HY-120907
CAS No.: 1197054-49-1
Sudemycin E is an analog of FR901464 (HY-16212). Sudemycin E can induce reversible changes in alternative splicing and abnormalities in chromatin modifications by binding to SF3B1, a component of the U2 small nuclear ribonucleoprotein (snRNP), thereby leading to the death of cancer cells. Sudemycin E has anti-tumor activity and can be used in tumor research .
Cat. No.: HY-122637
CAS No.: 2071636-70-7
Sudemycin K is a selective splicing inhibitor targeting SF3B1. Sudemycin K blocks U2 snRNP recognition of branch point sequences in pre-mRNA, inducing tumor-specific splicing deregulation and apoptosis. Sudemycin K is promising for research of SF3B1-mutated malignancies such as chronic lymphocytic leukemia (CLL) and myelodysplastic syndromes (MDS) .
Cat. No.: HY-P87080
Synonyms: Lea1 antibody; RU2A_HUMAN antibody; Small nuclear ribonucleoprotein polypeptide A antibody; SNRPA1 antibody; U2 small nuclear ribonucleoprotein A'' antibody; U2 small nuclear ribonucleoprotein polypeptide A' antibody; U2 snRNP A antibody; U2 snRNP A'' antibody;
Cat. No.: HY-P703295
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: U2AF2; U2AF65; U2 snRNP Auxiliary Factor Large Subunit; U2 Small Nuclear RNA Auxiliary Factor 2; Splicing factor U2AF 65 kDa subunit; U2 auxiliary factor 65 kDa subunit; hU2AF65; hU2AF65; U2 snRNP auxiliary factor large subunit; DEVDFB; HU2AF(65); Splicin
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
