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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
UBC13
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "UBC13" in MCE Product Catalog:
28
28 Cited Publications
Target:
Research Areas:
C25-140, a first-in-class, orally active, and fairly selective TRAF6-Ubc13 inhibitor, directly binds to TRAF6, and blocks the interaction of TRAF6 with Ubc13. C25-140 lowers TRAF6 activity, reduces NF-κB activation, and combats autoimmunity .
8
8 Cited Publications
Target:
Research Areas:
NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity .
Cat. No.: HY-157728
CAS No.: 3058650-52-2
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ML307 is a potent, sub-micromolar, first-in-class Ubc13 enzyme activity inhibitor with an IC50 of 781 nM. ML307 has the potential for immunomodulation and inflammation research .
Cat. No.: HY-125660
CAS No.: 151124-32-2
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Leucettamol A is an inhibitor of Ubc13 (ubiquitin E2 enzyme)-Uev1A interaction, with an IC50 of 50 μg/mL. Leucettamol A can potentially activate the expression of cancer suppressor p53 and is a precursor of anticancer agents. Leucettamol A can be isolated from a marine sponge, Leucetta aff. Microrhaphis .
Cat. No.: HY-184160
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Mcl1 Degrader-1 is an autophagy-targeting chimera (AUTAC) that selectively degrades the Mcl1 protein. Mcl1 Degrader-1 mediates K63 ubiquitination of Mcl1 via TRAF6/UBC13, transports it to autolysosomes for degradation through p62/SQSTM1, and activates Beclin1-dependent autophagy. Mcl1 Degrader-1 can be used in studies related to multiple myeloma and non-small cell lung cancer .
Cat. No.: HY-P79452
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: UBE2N; Ubiquitin Conjugating Enzyme E2 N; UBCH‑Ben; UBC13; Ubiquitin‑Conjugating Enzyme E2N (Homologous To Yeast UBC13); Ubiquitin‑Conjugating Enzyme E2N (UBC13 Homolog, Yeast); Ubiquitin‑Conjugating Enzyme E2 N; E2 Ubiquitin‑Conjugating Enzyme N; Ubiquit
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Cat. No.: HY-P704079
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: UBE2N; Ubiquitin Conjugating Enzyme E2 N; UBCH‑Ben; UBC13; Ubiquitin‑Conjugating Enzyme E2N (Homologous To Yeast UBC13); Ubiquitin‑Conjugating Enzyme E2N (UBC13 Homolog, Yeast); Ubiquitin‑Conjugating Enzyme E2 N; E2 Ubiquitin‑Conjugating Enzyme N; Ubiquit
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Cat. No.: HY-RS15356
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UBE2N Human Pre-designed siRNA Set A contains three designed siRNAs for UBE2N gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18303
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Ube2n Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ube2n gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P701564
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF8; Ring Finger Protein 8, E3 Ubiquitin Protein Ligase; Ring Finger Protein 8; UBC13/UEV-Interacting Ring Finger Protein; KIAA0646; Ring Finger Protein (C3HC4 Type) 8; RING-Type E3 Ubiquitin Transferase RNF8; C3HC4-Type Zinc Finger Protein; E3 Ubiquitin
Cat. No.: HY-P701565
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF8; Ring Finger Protein 8, E3 Ubiquitin Protein Ligase; Ring Finger Protein 8; UBC13/UEV-Interacting Ring Finger Protein; KIAA0646; Ring Finger Protein (C3HC4 Type) 8; RING-Type E3 Ubiquitin Transferase RNF8; C3HC4-Type Zinc Finger Protein; E3 Ubiquitin
Cat. No.: HY-P702815
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: RNF8; Ring Finger Protein 8, E3 Ubiquitin Protein Ligase; Ring Finger Protein 8; UBC13/UEV-Interacting Ring Finger Protein; KIAA0646; Ring Finger Protein (C3HC4 Type) 8; RING-Type E3 Ubiquitin Transferase RNF8; C3HC4-Type Zinc Finger Protein; E3 Ubiquitin
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
