343351-67-7
343351-67-7
Chemical Structure
NSC697923
- CAS No.: 343351-67-7
- Formula:C11H9NO5S
- Molecular Weight:267.26
IUPAC Name: 2-nitro-5-tosylfuran
InChIKey: GAUHIPWCDXOLCZ-UHFFFAOYSA-N
SMILES: O=S(C1=CC=C([N+]([O-])=O)O1)(C2=CC=C(C)C=C2)=O
Biological Activity: NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity[1][2].
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NSC697923 | 99.90% | NSC697923 is a potent UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13) inhibitor. NSC697923 induces neuroblastoma (NB) cell death via promoting nuclear importation of p53 in p53 wild-type NB cells. NSC697923 also induces cell death in p53 mutant NB cells by activation of JNK-mediated apoptotic pathway. NSC697923 inhibits DNA damage and NF-κB signaling. Antitumor activity. | ||||||||||||||||||||
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References
- [1]. Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5(2):e1079. Published 2014 Feb 20. [Content Brief]
- [2]. Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10(7):1718-1728. [Content Brief]
