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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
11 Results for "
UBD
" in MedChemExpress (MCE) Product Catalog:
Products (11)
11 Results for "UBD" in MCE Product Catalog:
3
3 Cited Publications
Target:
Research Areas:
USP5-IN-1 (compound 64) is a selective competitive inhibitor of USP5 zinc finger ubiquitin binding domain (ZnF-UBD) (KD=2.8 μM). USP5-IN-1 competitively blocks the binding of ubiquitin to ZnF-UBD, inhibits the catalytic activity of USP5, and thus hinders the hydrolysis of ubiquitin chains. USP5-IN-1 can inhibit USP5 cleavage of Lys48-linked diubiquitin substrates in vitro and is a potential USP5 chemical probe and potential inhibitor of USP5-related cancers.
1
Cat. No.: HY-172193
Synonyms: SGC-UBD1031
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UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC50 of 10.6 μM, KD value of 48 nM, and a human HDAC6-UBD KD of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome .
Cat. No.: HY-RS15335
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UBD Human Pre-designed siRNA Set A contains three designed siRNAs for UBD gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
SGC-UBD253, a chemical probe, is a potent HDAC6-UBD antagonist. SGC-UBD253 can be used in research of cancer .
Cat. No.: HY-157428
CAS No.: 2419322-41-9
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USP3 ZnF-UBD ligand-1 (compound 59) is a ligand that binds to the zinc finger ubiquitin-binding domain (ZnF-UBD) of USP3 with a KD of 14 μM .
Cat. No.: HY-RS17264
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Ubd Mouse Pre-designed siRNA Set A contains three designed siRNAs for Ubd gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS23718
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Ubd Rat Pre-designed siRNA Set A contains three designed siRNAs for Ubd gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-W027296
CAS No.: 6947-81-5
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UBTR008295a is a USP5 ZnF-UBD binder with a Kd of 80 μM. UBTR008295a interacts with USP5 ZnF-UBD. UBTR008295a is applicable for cancer research .
Cat. No.: HY-180994
HDAC6-IN-72 is a HDAC6 zinc finger ubiquitin-binding domain (ZnF-UBD) inhibitor that inhibits the interaction between HDAC6 ZnF-UBD and ubiquitin with an IC50 of 2.7 μM. HDAC6-IN-72 can be used for the research of breast cancer, colorectal cancer, multiple myeloma .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
