2. Cell Cycle/DNA Damage Epigenetics
  3. Deubiquitinase HDAC
  4. UBD1031

UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC50 of 10.6 μM, KD value of 48 nM, and a human HDAC6-UBD KD of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome.

For research use only. We do not sell to patients.

UBD1031

UBD1031 Chemical Structure

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25 mg Get quote 8 - 10 weeks 7 - 9 weeks 9 - 11 weeks 8 - 10 weeks
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Based on 1 publication(s) in Google Scholar

UBD1031 Related Antibodies

Top Publications Citing Use of Products

View All Deubiquitinase Isoform Specific Products:

View All Isoforms
USP1 USP2 USP4 USP7 USP8 USP10 USP21 USP30 UCHL1 USP11 USP15

View All HDAC Isoform Specific Products:

View All Isoforms
HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

  • Biological Activity

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  • References

  • Customer Review

Description

UBD1031 (SGC-UBD1031) is a selective USP16/HDAC6-UBD antagonist with a human USP16-UBD IC50 of 10.6 μM, KD value of 48 nM, and a human HDAC6-UBD KD of 16 nM. UBD1031 disrupts ISG15 C-terminus interactions with USP16-UBD and HDAC6-UBD, and exhibits cooperative inhibition of full-length USP16 deubiquitinase activity via USP16-UBD binding. UBD1031 can be used in research on cancer, autoimmune diseases, and Down syndrome[1].

In Vitro

UBD1031 potently binds purified USP16-UBD (residues 25-185) with an SPR-determined KD of 48 nM[1].
UBD1031 potently binds purified HDAC6-UBD (residues 1109-1215) with an SPR-determined KD of 16 nM[1].
UBD1031 (0.01 nM-10 μM) inhibits the deubiquitinase activity of purified full-length USP16 (USP161-823) with an IC50 of 10.6 μM, reaching up to 60% inhibition at maximal tested concentrations[1].
UBD1031 is at least 100-fold selective for USP16-UBD and HDAC6-UBD over seven other tested purified UBD-containing proteins (USP3, USP5, USP13, USP33, USP49, USP51, BRAP)[1].
UBD1031 (0.1-10 μM; 4 h) disrupts the interaction between USP16 and ISG15 in HEK293T cells with an IC50 of 1.7 μM[1].
UBD1031 (0.1-10 μM; 4 h) disrupts the interaction between HDAC6 and ISG15 in HEK293T cells with an IC50 of 1.5 μM[1].
UBD1031 (30 μM; 5 day) shows no detectable toxicity to HEK293T or HCT116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

UBD1031 Related Antibodies

Cell Cytotoxicity Assay[1]

Cell Line: HEK293T and HCT116 cells
Concentration: 30 μM
Incubation Time: 5 day
Result: No reduction in cell confluency was observed relative to DMSO-treated controls in either cell line.
Molecular Weight

449.84

Formula

C21H18ClF2N3O4
SMILES

OC(CCC1=NC2=C(C(N1CC(N[C@@H](C)C3=C(C=CC=C3F)F)=O)=O)C=CC=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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UBD1031 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UBD1031SGC-UBD1031UBD 1031UBD-1031DeubiquitinaseHDACDUBsHistone deacetylasesHEK293T cellsUSP13USP3HCT116 cellsUSP5HDAC6-UBDdeubiquitinase activityISG15USP16-UBDUSP16Inhibitorinhibitorinhibit

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