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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Urea Transporter
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Urea Transporter" in MCE Product Catalog:
1
1 Cited Publications
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UT-B-IN-1 (UTBINH-14) is a reversible, competitive and selective urea transporter-B (UT-B) inhibitor with IC50 values of 10 and 25 nM for human and mouse UT-B, respectively. UT-B-IN-1 shows low toxicity and high selectivity for UT-B over UT-A isoforms. UT-B-IN-1 increases urine output and reduces urine osmolality of mice. UT-B-IN-1 can be used for diuretic mechanism research .
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PU-48 is a blood-brain barrier-permeable urea transporter (UT) inhibitor with an IC50 of 0.32 μM against rat UT-A. By functionally inhibiting urea transporters (including UT-A subtypes) in the renal inner medullary collecting ducts, PU-48 induces urea-selective diuresis. PU-48 does not alter blood levels of sodium, potassium or chloride ions, nor does it affect the excretion of non-urea solutes. PU-48 shows no significant toxicity in cell or animal models and can be used in edema-related research .
Cat. No.: HY-131382
CAS No.: 332144-37-3
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UTA1inh-C1 is a urea transporter (UT-A) inhibitor with IC50 of 4.2 μM .
Cat. No.: HY-P702009
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC14A1; Solute Carrier Family 14 (Urea Transporter), Member 1; Prev. JK; Urea Transporter JK Glycoprotein; RACH1; Mutant KIDD Blood Group Antigen; Urea Transporter, Erythrocyte; Truncated Kidd Blood Group; Urea Transporter 1; Urea Transporter-B1; HsT1341
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Cat. No.: HY-124107
CAS No.: 1251688-22-8
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Research Areas:
UTA1inh-A1 is a urea transporter (UT) inhibitor. UTA1inh-A1 has IC50 values of 3.3 μM and 16 μM for UT-A1 and UT-B. UTA1inh-A1 can be used in research related to urearetics .
Cat. No.: HY-116718
CAS No.: 892745-28-7
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UTA1inh-D1 is a selective UT-A1 and UT-B urea transporter inhibitor with IC50 values of 3.8 μM and 15 μM, respectively. UTA1inh-D1 is promising for research of refractory edema, such as congestive heart failure and cirrhosis .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
