335394-78-0
Chemical Structure
PU-48
- CAS No.: 335394-78-0
- Formula:C14H12N2O3S
- Molecular Weight:288.32
InChIKey: XRJKHUHLPVGTCL-UHFFFAOYSA-N
SMILES: O=C(C1=C(N)C2=C(N=C3C=CC(OC)=CC3=C2)S1)OC
Biological Activity: PU-48 is a blood-brain barrier-permeable urea transporter (UT) inhibitor with an IC50 of 0.32 μM against rat UT-A. By functionally inhibiting urea transporters (including UT-A subtypes) in the renal inner medullary collecting ducts, PU-48 induces urea-selective diuresis. PU-48 does not alter blood levels of sodium, potassium or chloride ions, nor does it affect the excretion of non-urea solutes. PU-48 shows no significant toxicity in cell or animal models and can be used in edema-related research[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PU-48 | 99.76% | PU-48 is a blood-brain barrier-permeable urea transporter (UT) inhibitor with an IC50 of 0.32 μM against rat UT-A. By functionally inhibiting urea transporters (including UT-A subtypes) in the renal inner medullary collecting ducts, PU-48 induces urea-selective diuresis. PU-48 does not alter blood levels of sodium, potassium or chloride ions, nor does it affect the excretion of non-urea solutes. PU-48 shows no significant toxicity in cell or animal models and can be used in edema-related research. | ||||||||||||||||||||
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References
- [1]. Zhang ZY, et al. Development and validation of an LC-MS/MS method for the determination of a novel thienoquinolin urea transporter inhibitor PU-48 in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2018;32(4):10.1002/bmc.4157. [Content Brief]
- [2]. Zhang ZY, et al. Pharmacokinetics, Tissue Distribution and Excretion of a Novel Diuretic (PU-48) in Rats. Pharmaceutics. 2018;10(3):124. Published 2018 Aug 8. [Content Brief]
- [3]. Ren H, et al. Thienoquinolins exert diuresis by strongly inhibiting UT-A urea transporters[J]. American Journal of Physiology-Renal Physiology, 2014, 307(12): F1363-F1372.
